ID A0A255HCU9_9ACTN Unreviewed; 636 AA.
AC A0A255HCU9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CGZ93_01595 {ECO:0000313|EMBL:OYO25176.1};
OS Enemella dayhoffiae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Enemella.
OX NCBI_TaxID=2016507 {ECO:0000313|EMBL:OYO25176.1, ECO:0000313|Proteomes:UP000216311};
RN [1] {ECO:0000313|EMBL:OYO25176.1, ECO:0000313|Proteomes:UP000216311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML 130396 {ECO:0000313|EMBL:OYO25176.1,
RC ECO:0000313|Proteomes:UP000216311};
RA Bernier A.-M., Bernard K., Domingo M.-C.;
RT "Draft whole genome sequences of clinical Proprionibacteriaceae strains.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYO25176.1}.
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DR EMBL; NMVQ01000001; OYO25176.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255HCU9; -.
DR OrthoDB; 5241017at2; -.
DR Proteomes; UP000216311; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000216311}.
FT DOMAIN 96..157
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 167..318
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 373..539
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 636 AA; 65414 MW; B5B04E5003366800 CRC64;
MTLPRRPSPR PSDGDGWGDQ VHVRVAGAAL TALVLLSGCG GAGGDKPEQG KQPKTIEEAA
AAVAAGLSAG SLKDVPLRSG DPAADLPVLL RGLHGLQPKV TVQEVRRAGN TATVDFDYAW
PLSTEWTYET KATMVNESDT WKLVWEPAVL HPKLTAHNRL ERSRTSTDRG TITGRGSTVL
VQNTPLQMLG LNKAAVPDPG DQQASAETIA NQLNLDPVQF LEKVRAAGAN AFVDAAPVRT
EEIPANFTRT KGADSRTVTL PAAKSAGYAQ ALLGGVGYAG EKEVAESGGT VYPGDVLGTS
GLQKTFDAKL RGRGGNKVFL APRDSQPGSG RPTSDTLVAD FPDAPGGTLE TTIDDDVQSR
VEQAVGKVKQ PVSVAVIRVG NGAILAAADS PAARARNEST TARIAPGMAN ANVTALALLR
SGVRLNDKVT CEKSVTVEGL VVENPKGFSY NGSSMTLEQA LARGCRTAVA QAAGRLQADE
LSRAAQSLGM GRTVDLGTPN NLGAVERPTG ARATAETAIG QGPGVQASAL ALAVQAASVQ
AKKPITPVLV PERTPLAADG VPPLTEAESK ALQAMMKASP GSYGNFSNVV TGEADGRQVL
VGYSDAFAVA IVIGNAGDSS APSLSTLGRA ITSTGR
//
