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Database: UniProt
Entry: A0A255TNG2_9BACT
LinkDB: A0A255TNG2_9BACT
Original site: A0A255TNG2_9BACT 
ID   A0A255TNG2_9BACT        Unreviewed;       620 AA.
AC   A0A255TNG2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=CIK98_07045 {ECO:0000313|EMBL:OYP66774.1};
OS   Prevotella sp. P2-180.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=2024224 {ECO:0000313|EMBL:OYP66774.1, ECO:0000313|Proteomes:UP000216767};
RN   [1] {ECO:0000313|EMBL:OYP66774.1, ECO:0000313|Proteomes:UP000216767}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P2-180 {ECO:0000313|EMBL:OYP66774.1,
RC   ECO:0000313|Proteomes:UP000216767};
RA   Accetto T., Nograsek B., Avgustin G.;
RT   "Comparative genomics of non-oral Prevotella species.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OYP66774.1}.
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DR   EMBL; NPJI01000038; OYP66774.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A255TNG2; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000216767; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}.
FT   DOMAIN          209..327
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          437..579
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   620 AA;  69364 MW;  8E1FE5EEB3233B7A CRC64;
     MSDIIQLLPD SVANQIAAGE VIQRPASVIK ELVENAVDAG AKSIDVVVVD AGRTSIQVID
     DGKGMSETDA RLAFERHATS KINKADDLFA LHTMGFRGEA LASIAAVAQV KLKTRHKDNE
     IGSELEISAS KIVRQEPVSC PVGSNFMVEN LFFNVPARRK FLKTNSTELN NILTAFERIT
     LVYPEIAFTL HSNTTELINL RPGNLRQRIV DVFGKKLNHD LLPVEVNTQM CNISGFVGKP
     ESAKKKCTQQ FFFVNGRYMK HPYFHKAVMN AFERLVPVGM QVPYFIYFNV NPGDIDVNIH
     PTKTEIKFEN EQPIWQILTA AINDAIGKFC EIPSIDFDTE GQPDMPLFDP SQEIIAPPQP
     KYNADYNPFR PSETERRHNV PDKWEDLYRN IGSDSNTQEE PQLFPMSDDD SYTEIMPHDN
     GQQIVYENNE LTDRSPAHYQ YKATYIMTAV KSGLMIIEQH RADMRIKYER YLQQMCTQSA
     HVQQVLFPEV VHFPASSAVI LDKVLPELAK MGFDLSDLGQ GSYSINGVPA GMEGIDYRTL
     LVNMVAEAVE KGSPSLETIH KSLALTMARV AAIPTGQILT NLEMESLVNE LFACSNVNYT
     PDGKAILCIL PQSEIEQLMG
//
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