ID A0A255TT12_9BACT Unreviewed; 421 AA.
AC A0A255TT12;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Heavy metal-associated domain-containing protein {ECO:0000313|EMBL:OYP68280.1};
GN ORFNames=CIK98_03460 {ECO:0000313|EMBL:OYP68280.1};
OS Prevotella sp. P2-180.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=2024224 {ECO:0000313|EMBL:OYP68280.1, ECO:0000313|Proteomes:UP000216767};
RN [1] {ECO:0000313|EMBL:OYP68280.1, ECO:0000313|Proteomes:UP000216767}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P2-180 {ECO:0000313|EMBL:OYP68280.1,
RC ECO:0000313|Proteomes:UP000216767};
RA Accetto T., Nograsek B., Avgustin G.;
RT "Comparative genomics of non-oral Prevotella species.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0718 family.
CC {ECO:0000256|ARBA:ARBA00006386}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYP68280.1}.
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DR EMBL; NPJI01000025; OYP68280.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255TT12; -.
DR OrthoDB; 9770315at2; -.
DR Proteomes; UP000216767; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR005524; DUF318.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR NCBIfam; NF033936; CuZnOut_SO0444; 1.
DR PANTHER; PTHR34184; UPF0718 PROTEIN YCGR; 1.
DR PANTHER; PTHR34184:SF4; UPF0718 PROTEIN YCGR; 1.
DR Pfam; PF03773; ArsP_1; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 356..419
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 421 AA; 44699 MW; 541DC54D686CE029 CRC64;
MNQFIDLVTE MSPYLLLGFL LAGLMHAFIP GTIYSKYLAK PNMRSVVLAA LFGIPLPLCS
CGVLPTAMSL RREGASKGAA VSFLIATPQT GVDSIIATFS LMGLPFAIIR PIAALATAIF
GGKMVNVIEG DEGAGKFDST NEQAHDDLCG DSCCGGHDKV PTSFVGKVIE ALRYAYIDMM
ESVGKWLVVG LVVAGLITIF VPDSYFEIFK DNSFTSMLLV LCISIPMYLC ATGSIPIAVA
LMMKGLTPGA ALVLLMAGPA CSVASVLVVS KVLGRRTLIA YLGSIISGAV GFGLVTDYLL
PRAWFMSHLV ANDACCEEES SLFATSCTIL LFLLLANAFI RRRFCSKANI NSKNTMKQTF
VIKGMSCNHC RMSAEKAILS VKGVTSASVD LGSKQAVVEG DFSPEDVCKA VEETGFSCSL
L
//
