ID A0A255TVX8_9BACT Unreviewed; 1068 AA.
AC A0A255TVX8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CIK98_01360 {ECO:0000313|EMBL:OYP69035.1};
OS Prevotella sp. P2-180.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=2024224 {ECO:0000313|EMBL:OYP69035.1, ECO:0000313|Proteomes:UP000216767};
RN [1] {ECO:0000313|EMBL:OYP69035.1, ECO:0000313|Proteomes:UP000216767}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P2-180 {ECO:0000313|EMBL:OYP69035.1,
RC ECO:0000313|Proteomes:UP000216767};
RA Accetto T., Nograsek B., Avgustin G.;
RT "Comparative genomics of non-oral Prevotella species.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYP69035.1}.
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DR EMBL; NPJI01000013; OYP69035.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255TVX8; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000216767; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..468
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 492..738
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 10..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1068 AA; 122177 MW; 6D1A2AB73CB7F2E8 CRC64;
MSKTLTVYKA SAGSGKTFTL ATHYIKLLVE NPMQYRNILA VTFTNKATEE MKMRILSQLY
GIWHQYPDSK SYTDKLTEEL GCDVEYLRKQ VKTALHLLIH NYSFFRVETI DSFFQSVLRN
LARELDLTAN LRIELNDREV EGLAVDKMIE DLAINDDVMQ WIMDYIYDNM QEDKGWNVIG
QIKSFGLTIF KDFYKENDKA LVKAMEDSTF FEHYVKTLKE ERNQAKKVMQ DIAEEFFNTI
GEAGVSVDDF SFGKAGVCSL FLNIKEGPAG PDKTFNRAKD AKDKPDKWVS AKNPLKPTIM
ALVKSKLNTM LEEALSQNNG QWRRYQSATL TLRHLYKLRL LNVIEKSVRL MNEEAGRFLL
SDTQHLLHSL ISDNDSPFVF EKIGSRLEHI MIDEFQDTSV VQWKNFKVLL QECMSHAGSK
NLIVGDVKQS IYRWRAGDWR LLNDIENEFP NHSETVKIEN LDINFRSQAN VINFNNHFFS
TAAEMEKKAK EEKSAVSAQQ LQRAYSDVSQ KCKKNEINGL VTVKLFPSND YQLRTLEEVA
ANVRLLLNRG ARQSDIAILV RVNASIPLVA DYFAEHCPEV RIVSDEAFRL GSSIAIRIVV
LAMYLLTHPD DVLSTHSLAA LYQQHVLKAN ADLNSIFIDN ANVSSLLPEA FLNNIEKLLL
MPLYDLAKEL LQVFSVNDIE GQTGYICAFL DELNRFTTDT TTDIDTFVDE WNTSLCNKNI
RGDEVDGVRI LSIHKSKGLE YNNVIVPFCD WVLERSNVIW CQPKEEPYNQ LPLVPVDYSS
NALLGTVFEN DYITENLQNT VDNLNLLYVA FTRAGHNLFV YGRRKTASTR STLIEKCLPL
VTKDLPGASL NGVEDEKEAI CFSFGKLYIP ETLSEGKSQN VLLAKAEPLD VYYSQHQCRA
EFKQSNKSME FVGNDGDEHG YIKIGSIMHN VFSRIKTSDD INNAVDEIET EGLLDTIEKS
KSEILKIFHK RLQDPRVAEW FSPANKVYNE CTILTYDPKN NKVTECRPDR VVANGDTITV
IDFKFGTQKQ EYIVQVRDYM KQLHAMGHAN VKGYLWFVYN NIIEEVTL
//
