ID A0A255XLQ4_9PROT Unreviewed; 518 AA.
AC A0A255XLQ4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN ORFNames=CHR90_15555 {ECO:0000313|EMBL:OYQ17375.1};
OS Elstera cyanobacteriorum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Elstera.
OX NCBI_TaxID=2022747 {ECO:0000313|EMBL:OYQ17375.1, ECO:0000313|Proteomes:UP000216361};
RN [1] {ECO:0000313|EMBL:OYQ17375.1, ECO:0000313|Proteomes:UP000216361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH019 {ECO:0000313|EMBL:OYQ17375.1,
RC ECO:0000313|Proteomes:UP000216361};
RA Cai H.;
RT "Elstera cyanobacteriorum sp. nov., a novel bacterium isolated from
RT cyanobacterial aggregates in a eutrophic lake.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYQ17375.1}.
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DR EMBL; NOXS01000034; OYQ17375.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A255XLQ4; -.
DR OrthoDB; 9802795at2; -.
DR Proteomes; UP000216361; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 2.
DR Pfam; PF13742; tRNA_anti_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_00378};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378};
KW Reference proteome {ECO:0000313|Proteomes:UP000216361}.
FT DOMAIN 13..106
FT /note="OB-fold nucleic acid binding"
FT /evidence="ECO:0000259|Pfam:PF13742"
FT DOMAIN 129..353
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
FT DOMAIN 325..489
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
FT REGION 490..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 56254 MW; 74AD35487F5FB335 CRC64;
MTAPELTHNL PELSVGQLSN ALQRTVENAF PRVRVRGEIS GFKRAPSGHL YLTLKDPDAV
LGAVCWKGVA ARLSIRPEDG MEVIATGKLT TFAGQSKYQL VIDQMELAGR GALLALIEER
KRRLASEGLF EAARKRPLPL LPRVIGVVTS PTGAVIRDIL HRLNDRFPRP VLVWPVLVQG
EQAAAQIVAA IRGFNQLPDG GPIPRPDVLI VARGGGSIED LMAFNEEAVV RAAAASAIPL
ISAVGHETDT TLIDFASDRR APTPTAAAEM AVPVRAELRQ AVRERGQRLD QAADRLLQDR
NLRLDALARG LTDPRRAVAE ARQRLADRDQ RLQQAMRQRL AVQRASVATL GARLPHPQAQ
ITLARSRFVA EGKALDQSVQ RQVFVCGQRL DGLAARLRVE PLRQELGRQA QGLRQLADRL
PVAYAQMRRL REDRLGGLGR LLESYSYKGT LARGFVVLRD EAGALLSGLS ALPAGQRVVL
EAQDGTRTAE LLGEGAPPPT RPAKPKSKAA AATQESLF
//
