ID A0A256BNP7_9CYAN Unreviewed; 609 AA.
AC A0A256BNP7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=aspartate kinase {ECO:0000256|ARBA:ARBA00013059};
DE EC=2.7.2.4 {ECO:0000256|ARBA:ARBA00013059};
GN ORFNames=B9G53_01280 {ECO:0000313|EMBL:OYQ67409.1};
OS Pseudanabaena sp. SR411.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Pseudanabaenales;
OC Pseudanabaenaceae; Pseudanabaena.
OX NCBI_TaxID=1980935 {ECO:0000313|EMBL:OYQ67409.1, ECO:0000313|Proteomes:UP000215660};
RN [1] {ECO:0000313|EMBL:OYQ67409.1, ECO:0000313|Proteomes:UP000215660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SR411 {ECO:0000313|EMBL:OYQ67409.1,
RC ECO:0000313|Proteomes:UP000215660};
RA Stowe E.L., Hundermark E.L., Stowe W.;
RT "Novel uncharacterized cyanobacterium from Susquehanna River.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000709};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004766, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC {ECO:0000256|ARBA:ARBA00004986, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5. {ECO:0000256|ARBA:ARBA00005139,
CC ECO:0000256|RuleBase:RU004249}.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
CC {ECO:0000256|ARBA:ARBA00010122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYQ67409.1}.
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DR EMBL; NDHW01000034; OYQ67409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A256BNP7; -.
DR OrthoDB; 9799110at2; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR Proteomes; UP000215660; Unassembled WGS sequence.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04261; AAK_AKii-LysC-BS; 1.
DR CDD; cd04923; ACT_AK-LysC-DapG-like_2; 2.
DR CDD; cd04913; ACT_AKii-LysC-BS-like_1; 2.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR Gene3D; 3.30.2130.10; VC0802-like; 2.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR041740; AKii-LysC-BS.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR InterPro; IPR027795; CASTOR_ACT_dom.
DR NCBIfam; TIGR00657; asp_kinases; 1.
DR PANTHER; PTHR21499; ASPARTATE KINASE; 1.
DR PANTHER; PTHR21499:SF3; ASPARTOKINASE; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF01842; ACT; 2.
DR Pfam; PF13840; ACT_7; 2.
DR SUPFAM; SSF55021; ACT-like; 4.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR PROSITE; PS51671; ACT; 4.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OYQ67409.1};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000215660};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 287..362
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT DOMAIN 366..434
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT DOMAIN 457..535
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT DOMAIN 537..609
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 609 AA; 64473 MW; A22725C25AECC3BE CRC64;
MALIVQKYGG SSVADADRIK AVRDRIKRTV DAGNQVVVVV SAMGKTTDGL VALAESVSAT
YNQTLTEIAA KEREMDLLLA TGEQITIAAL SMALQAAGQP AIAMNGSQVR VVTEPNHTRA
RILYVEPDQI RSALDLGKVV VIAGFQGVAI DPATGLPSNE ITTLGRGGSD TSAVAIAAAI
NADICEIYTD VPGILTTDPR IVPKAQMLAE ITCDEMLELA SLGAKVLHPR SVEIARNFGV
KMCVRSSWLD DAGTVITSTG IGTGNLKSLE VNRFVETVSI DYDQVKIALL QIPDRPGIAS
QLFKSLADQG INVDLIIQAV QETEGVNDIA FTIPQNQLQL AEVVTRSLEI GASSVTVDAA
VAKISIIGVG MIGRPGVAAQ MFTALAEAGI NIQMISTSEI KISCVIAAAD GEAAIAAIQK
TFDVPVRSHQ ACEITSEQNS DISPVRGVAL DRNRARIAVQ QVPDRPGMAA KILEQLVEQN
ISLDMIVQSQ SDRDVNEIAF TVAITDLAKA ETALNQYTKE LGYGEVTCDA DISKVSIVGA
NMIHQSGIAA RMFSALADSG INIEMIATSE IKVSCVVRDH QAEQALKVIH QEFNLSGDRA
IEVPSALKK
//
