ID A0A256CU27_9GAMM Unreviewed; 1163 AA.
AC A0A256CU27;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=B9T19_02650 {ECO:0000313|EMBL:OYQ81588.1};
OS Ignatzschineria sp. F8392.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cardiobacteriales;
OC Ignatzschineriaceae; Ignatzschineria.
OX NCBI_TaxID=1980117 {ECO:0000313|EMBL:OYQ81588.1, ECO:0000313|Proteomes:UP000215803};
RN [1] {ECO:0000313|EMBL:OYQ81588.1, ECO:0000313|Proteomes:UP000215803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F8392 {ECO:0000313|EMBL:OYQ81588.1,
RC ECO:0000313|Proteomes:UP000215803};
RA Gulvik C.A.;
RT "Wohlfahrtiimonas and Ignatzschineria genomes.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYQ81588.1}.
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DR EMBL; NEFF01000001; OYQ81588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A256CU27; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000215803; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1163 AA; 132270 MW; C4275AB5C5A8605D CRC64;
MTFTHFNLHT EFSMVDGLIR IKPFFAKLKE MGMRAAALTD LGNEFAAIKF YETALKSGIK
PIFGADCLVI DEESSVGRIT LIAQDYQGYL NLAELLSYGY RYHQIRGVPY ITHEKLMEYQ
AGLIVIMAKE SHFGQKLLNQ GAPAAERFLQ SVYPAFLEDR LYIGIKRLEQ QDDERFIQMA
APFAEAHHLP LIALNDVRFM QEDEFEAHEV RVAIQSGYSM LDPNRPRNYS PKQYLRSIEE
MEALFADFPD AIENSIELVK RCNVTLTLHK PQLPAFPIPE GMTIEEYFKA ESYRGLEERI
GKQSEANQHY WERLDIELNV INNMGFPGYF LIVADFIQWA KDHQIPVGPG RGSGAGSLVA
WALKITDLDP LPYDLLFERF LNPERVSMPD FDIDFCMEGR DRVIEYVANR YGREAVSQIA
THGTMAAKAV IRDVGRALGH PYGFVDRIAK LIPMDIGITL EKAMMQEPEL HDLYHQDEEV
KILIDLAKQL EGLAKSVGRH AGGVVIAPTK LTDFSPLYCE EGSTALVTQY DKDDIEAAGL
VKFDFLGLRT LTIIDWAIKN IAYNRGETID LHDLPLDDKP TFELLKACQT TSVFQLESRG
MKDLLRRLQP DNFEDIVALV ALFRPGPLES GMVEDFINRK HGREEVIYPF PELEPVLKPT
YGVIVYQEQV MQISQIIGNY SLGGADLLRR AMGKKLPEEM EKQRALFMQG AETLGFDSEK
AGRLFDLMEK FAGYGFNKSH SAAYALLSYQ TAYLKQHYPP EFMAAVLSAD LDHTDKIIII
IEEVLAMKIP IIRPSINHSY HQFTVNREGA IIYGLGALKG YGKAAALQLI EEREENGPYL
DLFDFCRRID LSKTTKRAID ILIRAGALDC LNPEIESIQE RAAYRAQLLA TMEEAIRLAD
QNRKNENSGQ GDIFGLFSDE PSDEPQYQLQ SAMPLTETAL LHAEKSVLGF FFSGHPIDQY
RAEIKEVANT TLTALQAMPE PQYHSRNEDN VIVAGLVTAF YTRISKAGKK MFFVVLDDGH
ARAEFRLFEE PIETLNEAGE EIEPDTILFI RGSHSWDSFN NCMTLRVSEL QTLKQVRERH
GHFILIENRR PLSLTTVQEI FQKLMPHRDD EKGLQLIFKY HNPRSAGVLQ MQQEKVIADD
ELLVSLKQQY HDEIDLSVGY RKR
//
