ID A0A256IJ09_9EURY Unreviewed; 968 AA.
AC A0A256IJ09;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=site-specific DNA-methyltransferase (cytosine-N(4)-specific) {ECO:0000256|ARBA:ARBA00012185};
DE EC=2.1.1.113 {ECO:0000256|ARBA:ARBA00012185};
GN ORFNames=DJ70_08595 {ECO:0000313|EMBL:OYR56484.1};
OS Halorubrum halodurans.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=1383851 {ECO:0000313|EMBL:OYR56484.1, ECO:0000313|Proteomes:UP000216308};
RN [1] {ECO:0000313|EMBL:OYR56484.1, ECO:0000313|Proteomes:UP000216308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cb34 {ECO:0000313|EMBL:OYR56484.1,
RC ECO:0000313|Proteomes:UP000216308};
RX PubMed=24782836; DOI=10.3389/fmicb.2014.00140;
RA Fullmer M.S., Soucy S.M., Swithers K.S., Makkay A.M., Wheeler R.,
RA Ventosa A., Gogarten J.P., Papke R.T.;
RT "Population and genomic analysis of the genus Halorubrum.";
RL Front. Microbiol. 5:140-140(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYR56484.1}.
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DR EMBL; NHPJ01000085; OYR56484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A256IJ09; -.
DR OrthoDB; 38200at2157; -.
DR Proteomes; UP000216308; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000216308};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 466..736
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
FT REGION 391..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 968 AA; 110622 MW; 686A492F0A7F8AEA CRC64;
MNSETCKSAV ELEMLASGMA KQHENFLDAT QELVDNSVAA VVDGESYFDE PDERINISIS
FVRGEETVTT YISDNGPGIT REDLQNHVFR TGNKEISEGI LNNVGWGLKA SLAWFEESLK
QRDLEDDTHW FSLVTQTTES DCLRVDGPIT GDLPIVDATE SQWKIGVPDG VDPLLQADHG
TRIHATCARS QFDSDVWPSA DSLGTKIQYI RERLGVMFRR LLSARDDNQI VIHYHDLPSN
EQGTFEVPPI SPSYTDETEQ KSRQFHVSTP QGDRYQVRYE AGTLDIDSMT KWAEKEYPDL
LTQSGKFRYR YRPSQNRQGI DIYANGRVLM TSVFEDLFDL TRNNQYNYFG GTLRIFPIGD
TDEVPTDNKK TRLDTNSELW RKIREELSDE ELLPEGREYG KRVSSGGAST TNQIPEEEES
AEELASTPTF DSNSDIFGLH HGDAKSIIPA IRDHATDTLN EQAEFVDTTI TSPPYYDLKE
YGSSEENEIG QHGSYVEYLQ ELQNLFSEVY SVTRDDGSLW VVVNTFRRNR EIVQLPFDIA
RICQNLDQGL ECSNCENTIL RGVEELDSRQ TACPHCGHTT DNDESWILQD IVIWNKNRAL
PYTKEGRLRN VFEYILCFSK NPEFELQMDR IRESDPAQFK KWWADFPERY HPLGKLPENI
WEFEPPTRGS FTGEVDVFDH PAAFPPELIE QILTLSTESD DIVLDPFAGS GVVLGQSELM
DRRPIGVELN KKYCDVYPAL REYLEDQHEE QDQVASQENL AQIICGLRQT KYARELLRTM
AGELGLSSPS QLDVHTTFLV SRELGYQSVE NDVHGQIDLI LLVDDETTAR QALDYDEKAE
EVTTIQPCSG FGIRARTLVL TVEEFINEIA NDTYTHLPEE LFIYEDGRHY VYSEGISYDE
WRKLNDGSDQ WTERYSDDKI PPIVSNIGME INHPKHSMET VSRELSGNHE MQLHRSEGGH
RKHIIRRS
//