ID A0A256YPR0_9ARCH Unreviewed; 250 AA.
AC A0A256YPR0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000256|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000256|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000256|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000256|HAMAP-Rule:MF_00317,
GN ECO:0000313|EMBL:OYT42478.1};
GN ORFNames=B6U78_01095 {ECO:0000313|EMBL:OYT42478.1};
OS Candidatus Aenigmarchaeota archaeon ex4484_224.
OC Archaea; Candidatus Aenigmarchaeota.
OX NCBI_TaxID=2012503 {ECO:0000313|EMBL:OYT42478.1, ECO:0000313|Proteomes:UP000217063};
RN [1] {ECO:0000313|Proteomes:UP000217063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K.W., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- FUNCTION: Sliding clamp subunit. Responsible for tethering the
CC catalytic subunit of DNA polymerase to DNA during high-speed
CC replication. {ECO:0000256|RuleBase:RU003673}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|HAMAP-Rule:MF_00317, ECO:0000256|RuleBase:RU003671}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYT42478.1}.
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DR EMBL; NJEA01000007; OYT42478.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A256YPR0; -.
DR Proteomes; UP000217063; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00317,
KW ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00317}.
FT DOMAIN 1..101
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 124..245
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
SQ SEQUENCE 250 AA; 28258 MW; 1706F8E4789D4EC7 CRC64;
MFKAVLTDPD LLRIPITTIA QLIDEGVFNI TKSNISLRAA DRAMVAVVDF KILANAFEEY
SIEEESKIGL NVSNFLSILK RAKRKDKLEM SLKENRLEIL LTNGSRRRFS LPLIEIGEEE
VPPIEQLEFT AKAEIRPEVL EDAIKDAEIV SDVILFLANK DKFIMKAEGD ISQAEVVLEK
GSENLLSLNV KGNEVKARYP IDYLKKMVKA SKLADTIVIE FANDYPMKLS FRVLDKVDLT
FVLAPRVIEE
//
