GenomeNet

Database: UniProt
Entry: A0A256YZ03_9CREN
LinkDB: A0A256YZ03_9CREN
Original site: A0A256YZ03_9CREN 
ID   A0A256YZ03_9CREN        Unreviewed;       424 AA.
AC   A0A256YZ03;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE            Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
GN   ORFNames=B6U85_08430 {ECO:0000313|EMBL:OYT45663.1};
OS   Desulfurococcales archaeon ex4484_42.
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales.
OX   NCBI_TaxID=2012520 {ECO:0000313|EMBL:OYT45663.1, ECO:0000313|Proteomes:UP000216823};
RN   [1] {ECO:0000313|Proteomes:UP000216823}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dombrowski N., Seitz K.W., Teske A., Baker B.;
RT   "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT   hydrothermal sediment communities.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OYT45663.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NJDT01000094; OYT45663.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A256YZ03; -.
DR   Proteomes; UP000216823; Unassembled WGS sequence.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR   Gene3D; 1.10.8.660; -; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR   PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR   PROSITE; PS01192; HMG_COA_REDUCTASE_3; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU361219}.
SQ   SEQUENCE   424 AA;  45616 MW;  CD96FBB5509675BF CRC64;
     MSEKTSRLPG FYKLSIDERL KIVKEFAGLT DEEVKLLSNF GNLGADKANV MIENVIGGMT
     YPFAVAVNFL INGKEYLVPM VLEEPSVVAA ASNAAKVMRR DGGIKAKATD PIMIGQIQVI
     NVPSPHHARM IVLEHRDEIL DLANAQDPIL VKLGGGAKDV EVRVVNSRIG PMLIVHLLVD
     VRDAMGANAV NTMCEAVAPL IEKLTKGKVL LRIISNLAVK RLVRAWVKVY KEDIGGEDVV
     DRIVAASAFA EADPFRATTH NKGILNGVIA VALATAQDHR AIEAGAHAYA ARDGRYKPLS
     IWEKDDEGNL VGFLEMPMAV GIVGGATKTH PTARIALKIL GVKSAKELAE VMGAVGLAQN
     FAALRALATV GIQKGHMKLH ARNLAIMAGA EGELIDKVAE RMIEEGKITY ARAVEILKEL
     KGEE
//
DBGET integrated database retrieval system