ID A0A256YZ03_9CREN Unreviewed; 424 AA.
AC A0A256YZ03;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
GN ORFNames=B6U85_08430 {ECO:0000313|EMBL:OYT45663.1};
OS Desulfurococcales archaeon ex4484_42.
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales.
OX NCBI_TaxID=2012520 {ECO:0000313|EMBL:OYT45663.1, ECO:0000313|Proteomes:UP000216823};
RN [1] {ECO:0000313|Proteomes:UP000216823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K.W., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYT45663.1}.
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DR EMBL; NJDT01000094; OYT45663.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A256YZ03; -.
DR Proteomes; UP000216823; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR Gene3D; 1.10.8.660; -; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS01192; HMG_COA_REDUCTASE_3; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361219}.
SQ SEQUENCE 424 AA; 45616 MW; CD96FBB5509675BF CRC64;
MSEKTSRLPG FYKLSIDERL KIVKEFAGLT DEEVKLLSNF GNLGADKANV MIENVIGGMT
YPFAVAVNFL INGKEYLVPM VLEEPSVVAA ASNAAKVMRR DGGIKAKATD PIMIGQIQVI
NVPSPHHARM IVLEHRDEIL DLANAQDPIL VKLGGGAKDV EVRVVNSRIG PMLIVHLLVD
VRDAMGANAV NTMCEAVAPL IEKLTKGKVL LRIISNLAVK RLVRAWVKVY KEDIGGEDVV
DRIVAASAFA EADPFRATTH NKGILNGVIA VALATAQDHR AIEAGAHAYA ARDGRYKPLS
IWEKDDEGNL VGFLEMPMAV GIVGGATKTH PTARIALKIL GVKSAKELAE VMGAVGLAQN
FAALRALATV GIQKGHMKLH ARNLAIMAGA EGELIDKVAE RMIEEGKITY ARAVEILKEL
KGEE
//