ID A0A256ZVP6_9CREN Unreviewed; 1725 AA.
AC A0A256ZVP6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=B6U76_02960 {ECO:0000313|EMBL:OYT56695.1};
OS Desulfurococcales archaeon ex4484_217_2.
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales.
OX NCBI_TaxID=2012519 {ECO:0000313|EMBL:OYT56695.1, ECO:0000313|Proteomes:UP000216854};
RN [1] {ECO:0000313|Proteomes:UP000216854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K.W., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYT56695.1}.
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DR EMBL; NJEC01000030; OYT56695.1; -; Genomic_DNA.
DR Proteomes; UP000216854; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd00081; Hint; 2.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 4.
DR Gene3D; 3.10.28.10; Homing endonucleases; 2.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01443; intein_Cterm; 2.
DR NCBIfam; TIGR01445; intein_Nterm; 2.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF43; DNA REPLICATION LICENSING FACTOR MCM6; 1.
DR Pfam; PF14890; Intein_splicing; 2.
DR Pfam; PF14528; LAGLIDADG_3; 4.
DR Pfam; PF00493; MCM; 3.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR00379; INTEIN.
DR SMART; SM00305; HintC; 2.
DR SMART; SM00306; HintN; 2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 2.
DR SUPFAM; SSF55608; Homing endonucleases; 4.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS50818; INTEIN_C_TER; 2.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 2.
DR PROSITE; PS50817; INTEIN_N_TER; 2.
DR PROSITE; PS50051; MCM_2; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000}.
FT DOMAIN 296..353
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT DOMAIN 513..670
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 835..859
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
FT DOMAIN 859..937
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT DOMAIN 1087..1236
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 1437..1459
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
FT DOMAIN 1452..1530
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 1725 AA; 197153 MW; A7335D2F1E9FAC0E CRC64;
MENTIDEEKE GLGEVTILGD PKEEFIKFLK TFKDIHGKLK YWDKVLDMTI KGERSIVIDF
PDLYITNPQL ALYVVENPRE ALDYASQALK ELVANENREL AAKIDRFYVR FRDLPETVPI
RRLGSEHIEK LIQIEGVVTR MTPTMERLYK AVFQCTNCGT EIEVIQEGDT LEYPTECACG
GKPSFKLLLH KSKFIDIQKI MVQERPEEIP PGQLPRSIEV VLTEDLVDKA RPGDRVTIVG
ILTIKGERSV KKGSKLTFEM RIEANNVEVS QKVLEELEIS KEDERKILEL ARDPKIREKI
INSVAPAIYG YEHIKKAIAL LLFGGVPKEL RDGTRIRGDI HVLLVGDPGT AKSLVYSERI
LVLDENGLIS FRPIGEIVDE YMGKYRDKVV TQGETEELLL DKVGVKLYTI AISPVTLKPE
IKPIKALIRH KAPRKVVVIK TKHGRRVIVT KDHSLIGFDK DSATLIPIKP AKALEKRVLL
PILKNLAPFR RNIVNSVKVG NQNIKLDWDF GYLIGFFLGD GTVSKVTSGE RIEIVSTNKE
VIEYLKRVVQ YRLKLSPKVY ERNGRDRKQY RLIITDEEFI DWIKRNCFTK ISREKRTKGL
LSRYKRIPQM AFNAPIAFIE GLISGLIESD GSIIPSGIKK SRYWKGEITI STISENLAHD
ISVLLAILGL NHTIRYCSLK YRDRNVRYFR IYVPDTNIIR LMRLIDPVKQ EKLKHTYVNG
NTVIDKAPMT STVIKVLSLL KLNSRKRGYR NFAGEVRGKV YRGYVGRNYA YKVLNKLSEL
AKKYQSIGSE SLEKQTFTTL NKLDSIINNT TITWDVIESI EEVDICKIEP NHNEHVYDVS
VEGYENFVGG LGLLFLHNSQ LLQYVARIAP RGIYTSGKGS TAAGLTAAVL RDKSTGEYYL
EAGALVLGDG GIVCIDEIDK MRAEDRVAIH EAMEQQSYHK DFELLLANGR KVKIGELVDR
LIANNKDRVI SGVETEILPV NNIEILSYDF ISKNIVKIKA NRVSRHKAPR KFIKITYNNG
RTIIVTPEHP IFIWNNGKII TIRADNVKPG MLVPSIRYYP EKLSNNDLLS RALIEFRTKA
PETLAKFIGY ILSDGFVYSN EKRGYYEIGF ANTNTALIEE FKEILEKLNI KYTIQVSSKG
RKRTLYIIRT LSKGLYDKIT KLLPEIVPPK DNQRKRPSTL RRIPSLIFVM SEEAKKAFLN
AYFKGDGFVD KYRVGFRTSS RKLAEDLQDL LLTLKIRSYI YAEKIKGREY YKVVIHGTDD
IERFATIIHD DPRYNRVLKL LSKSQRKLNY RDPMPFEVAR KLREVLNELN LNDGYVTNIV
KRKATIHREK VCKYIQLIEN KLKAIRRAVE RNDLTMIRKF VSLRELSVKM GIPYSTLRYR
LIIKKDKEVI RTLIMQAINK LKKIEEIVNE IKSLAYGNIM FLRVKAVEEV ENKDSEWVYD
VTVEPNHTFI SHGLILHNTI SIAKAGIVAK LNARASILAA GNPVLGRYIR ERGFLHNINL
PPTILSRFDL MFVMVDEPAP ERDEEMAEHI LMVHKRTEKI KPPIDPELLR KYIGYARKYV
KPKLSDEAVK IIKDFFVSLR AKAATSAEVA VPITPRQLEA LVRLAEAHAK MALSNIVTAE
DAKAAIDLMV RSFKDVGIDV ETGEIDIDII MTGKPLSLRK KMLKIMNIIE RLEGGVPGTQ
VNLRDVIEEA KKEGISERDA EEIIETLRRE GQIYMPKEGK IARLI
//
