ID   A0A257C8S7_9BURK        Unreviewed;       335 AA.
AC   A0A257C8S7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:OYT84899.1};
GN   ORFNames=CFE46_18855 {ECO:0000313|EMBL:OYT84899.1};
OS   Burkholderiales bacterium PBB6.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX   NCBI_TaxID=2015568 {ECO:0000313|EMBL:OYT84899.1, ECO:0000313|Proteomes:UP000216978};
RN   [1] {ECO:0000313|EMBL:OYT84899.1, ECO:0000313|Proteomes:UP000216978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PBB6 {ECO:0000313|EMBL:OYT84899.1};
RA   Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA   Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT   "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT   formosa and its bacterial cohort.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC       ECO:0000256|RuleBase:RU003719}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OYT84899.1}.
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DR   EMBL; NKIH01000008; OYT84899.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A257C8S7; -.
DR   Proteomes; UP000216978; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd12169; PGDH_like_1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR   PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000216978}.
FT   DOMAIN          39..327
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          111..296
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   335 AA;  36664 MW;  9ED08D5CB3F040C9 CRC64;
     MNIIILDDYQ DAVRKLPSAS KLNDLNAKVF TNTVKGLGQL SVRLRDAEVL VAIRERTHFN
     RQLLEKLPKL RLIAQTGRVG NHIDIDACTR LGIAVAEGVG SPNAPAELTW ALIMAAMRRL
     PQYIGNLKHG AWQQSGLKSQ SMPPNFGIGM QLRGKVLGIW GYGKIGAIVA GYGKAFGMDV
     RVWASAPSRA RALADGYCVF ESREELFTQS DVLSVHLRLA DHTRHLVTHG DLSSMKPTAL
     FVNTSRAELV EDAALVSALN RGRPGMAAVD VFETEPILQG HPLLRLENAV CTPHIGYVEQ
     DSYEMYFGAA FDNVVNFVNG TPSNIVNPDA LKVLR
//