ID   A0A257ELV0_9PROT        Unreviewed;      1921 AA.
AC   A0A257ELV0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:OYU14784.1};
GN   ORFNames=CFE37_09265 {ECO:0000313|EMBL:OYU14784.1};
OS   Alphaproteobacteria bacterium PA4.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria.
OX   NCBI_TaxID=2015572 {ECO:0000313|EMBL:OYU14784.1, ECO:0000313|Proteomes:UP000215773};
RN   [1] {ECO:0000313|EMBL:OYU14784.1, ECO:0000313|Proteomes:UP000215773}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA4 {ECO:0000313|EMBL:OYU14784.1};
RA   Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA   Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT   "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT   formosa and its bacterial cohort.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OYU14784.1}.
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DR   EMBL; NKIQ01000017; OYU14784.1; -; Genomic_DNA.
DR   Proteomes; UP000215773; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215773}.
FT   DOMAIN          1011..1188
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1248..1338
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1921 AA;  202404 MW;  E978C9F3BE4A7A58 CRC64;
     MTRSGWIIGA ALLALAAAGA VVNGAPTARV DRFSPRGAVQ GPEQIAVHFT TPMVALGDPR
     LPAPVTGNCS AGATGRWADA QSYVVDLPAP LPGGQRCRYD LQPGLKDLRG APVGGQQRFE
     FDTGGPAVRG TLPFGGTVEE DQVFLLALAA PPTAASVAAN AACLIEGVGE AVPLDILPDK
     TRDSVIGGAA GDYSVRRFME IAGWRKAEYG DDVTPPRATI LAAKCRRTLP PGGKLGIIWG
     GGITTANGLT VAAPNRLAFT VRPAFTARFE CSRVNAAAAC SPLQAMRLAF AGEVPLADAL
     AVRLIGPDGK AIAPMAPKNR VTTVGQVEWP ALFVARSDYR IALPPQLRDD AGRPLANAAR
     FPLAVATGEF PPLAKFGGTF GIIEAAEGGV LPVTLRGIER PLAAGGTTLA ARDLPVASDA
     AVAAWLRRLD KAEERSFIEE PIAGSEDRRT IETTRSTPLI ASGSGARGFR IERDRDPRRL
     EVVGIPLKTR GFHVVEIASP ALGAALLGAG RTRYVATGAL VTDLAVHWQW GKGRSLAWVT
     RLADATPVAG ARIAISDSCT GKLYWQGRTD RSGRALIGDV LPPPNSYGSC DSDDSHPLMV
     SARTADDYSF TLSTWGNGIQ GSDFSLPQGW GYEPKAVHTV FDRTLLRSGE TINMKLISRL
     RSDAGFGPSP AITARTLTLR HLGSDTEFAT PLTVAGSIAT ARWTVPRTAP LGDYQVLLNE
     TGGARDAGAF KVEEYRLPTI RASVSGPRQR LVAPRQVPVD LALTYLSGGA VASAPVKLRT
     IVEPRTVKVS GYDNWSFNSE NVVPGIVPLG SDGEEPDAGR APLRAAMQPV ALGPKGVARL
     LVDVAAVTGP SQLVAEMDYD DANGEVATTG SRIDLEPAAL RVGIRTDGWL AKSDDLRLQL
     VVVDLEGRPV RNQRVRVKLF SRETYSYRKR LIGGFYAYDN SRETREIGSG CTGTSDAQGR
     LGCRLDAGIS GEVLAVADVS DAAGRTARAS TSVWLAGDDD WWFGGDNGDR MDVVPENARL
     AANGIARLQV RMPFRSATAL VTVMRDGVID SFVTTLSGKD PVVEVAMKPG YAPDVYVSVL
     AVRGRVAGWR LWLADLARRW NLPWLSREAA SPTALVDLAK PSYRLGMARL TVGWERNRLG
     VTVASDRPSY PVRSAAGAKV TVIPPKGRAL PRDAEIAFAA VDEALLQLQP NDSWDVLSAM
     MAERPLGVSF ATAQTQVVGK RHYGRKAVAA GGGGGSGAAL VRRDFNPVLV WRDRVRLDAR
     GQALVPLRLN DSLSGFRLVA VATAGNDLFG TGMTTIRTTQ DLQLLPGIPP FARDGDAYVA
     TVLARNTTTA PMRVRLTGSA GTLRLPPLDL TIPAGGAQTA AWRVVAPAPG RIVWQIAAHA
     AGGQTDQVAV TQTITPAVPV ETWQASFFQA GGSALPMASP AGALPGQGGV TVALSGSLGG
     DLPGVRAYMA AYPYDCIEQQ LSRAVALGDR AGWDRAAAAL PGYLDGNGLV RFFPADWIAG
     DDALTAYVLR LSAASGWPLP ETARAPMIAG LTGFVMGRVV RSHADVLVVD KGSGRATRAD
     LSGDEPVRLV TAVSALAAVG AARPTMLEPL NVTPDNWPTV TVIDWIGLLE RLPVPGGAAR
     MAQAEAVLRA RLDVQGTTLR LNRSDAPFQL LASPDATAAQ LLALAVRRPA WRSEAPRIAR
     ALMLAQRRGH WDTTPANALG TLAVRDFQRA FEAAPVTGAT RVALGGQQRS FDWAGTPAPQ
     ILPWPVGTAS LGVRHTGAGA PWVMVTARAA VPLTKAFASG FGLSRQVSPV TQAVPGQWSR
     GDVMRVRLTI TPRAPAEWVV INDPVPAGAT ILGGTLGGRS QLLADAEGSG NGMPPSFVER
     RGDAVHAHYA ALTRAPVIYD YTLRLGSVGS FRLPPTRVEA LYAPDMMAML PNAPLVVAPA
     P
//