ID A0A257HYW7_9BACT Unreviewed; 1050 AA.
AC A0A257HYW7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Hydrophobe/amphiphile efflux-1 family RND transporter {ECO:0000313|EMBL:OYU55813.1};
GN ORFNames=CFE25_00750 {ECO:0000313|EMBL:OYU55813.1};
OS Chitinophagaceae bacterium BSSC1.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae.
OX NCBI_TaxID=2015574 {ECO:0000313|EMBL:OYU55813.1, ECO:0000313|Proteomes:UP000217121};
RN [1] {ECO:0000313|EMBL:OYU55813.1, ECO:0000313|Proteomes:UP000217121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSSC1 {ECO:0000313|EMBL:OYU55813.1};
RA Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT formosa and its bacterial cohort.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYU55813.1}.
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DR EMBL; NKJC01000001; OYU55813.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A257HYW7; -.
DR Proteomes; UP000217121; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000217121};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 369..494
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1050 AA; 113830 MW; AE78879405F47CCF CRC64;
MSEFFIRRPI VAMVISIFIV IMGLLTLQGI PVAKYPDITP PMVQVQAAYT GANAVDMEQT
VATPIEQQVN GVENMLYMKS VNYNGSMTLQ VSFEVGTDLD VANMLTQNRV SRANPFLPPE
VINLGVNVKK SLTFPLMMFS VYSPSKSYNA DFINNYAFIN LIDELKRIKG VGDVSVMGSS
EYAMRIWVKP DRLAKLKITA SDVMNAIKAQ NNIVPGGAFG DAPSKPGIQN TYTATLQQRL
VSEEDFGNIL LKSNANGAQV RLKDVARIEL GLQMYNLSSN LNGSPCAAIA IYQIPGSNGL
DVANKAKAKM DELKSRFPQG LDYTTSLDTT QAITVGIEEV LHTLFEAVIL VILVVFLFLQ
DWRATLIPLL TVPVSLIGTF IVFPLLGFSV NQLSLLGMVL AIGLVVDDAI VVVEAVIHEM
EHGLNPKEAT SKAMKEVGGP VVAIAVILCA VFIPVALSGG ITGRLYQQFA ITIAISVALS
AFNALTLSPA LAAILLKPKK PSKGLLQRFF DGFNKYFDKF TNGYVKVASF AARKLFLTVM
ILLGICAATG YLALKVPGGF VPEEDEGYFM LAIQLPDAAS KDRTEAISKK VESYFKGMEE
ISSYTAINGF NILSGTATPN SAMAFISLKP WDERHKTVAQ IVNEMNAVLT KNITEATVIV
FGPPPIQGLG SGAGFTMMLQ DKAGKSPLYL AQQTQRFIAI ASKRPEIGKI YTLFRPTVPQ
KSIQVDKEKV QKMGIPLQEV NGAISAYLGG AFINNFNAYG RQYRAYIQSE AEYRMKPDDI
NQYFVRDPNG NMVSLGTLAK VKDTTGPSFT NHFNIYRSAE LSGVPAPGVS SDMALRVLEG
VAKKVLPNDI GYSWSNTSYQ EKESAGKGAS VFIMALLFVF LILAAQYESW KLPFSVLLGT
PWAVMGALLG LFIGGLYATT YVNNVFAQIG LVMLIGLNAK NAILIVEFAK MKMDNEGLAP
FEAAIEGARL RFRPILMTSF AFILGVVPLM TATGAGAEAR RVMGTSVFSG MLVATIVGVI
LIPAFFVLIE GKKKKKATVA PATETNHSTH
//
