ID A0A257KCY3_9FLAO Unreviewed; 392 AA.
AC A0A257KCY3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=CFE24_02670 {ECO:0000313|EMBL:OYU85224.1};
OS Flavobacterium sp. BFFFF2.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2015558 {ECO:0000313|EMBL:OYU85224.1, ECO:0000313|Proteomes:UP000216176};
RN [1] {ECO:0000313|EMBL:OYU85224.1, ECO:0000313|Proteomes:UP000216176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BFFFF2 {ECO:0000313|EMBL:OYU85224.1};
RA Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT formosa and its bacterial cohort.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYU85224.1}.
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DR EMBL; NKJD01000005; OYU85224.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A257KCY3; -.
DR Proteomes; UP000216176; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF171; ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:OYU85224.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000216176};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:OYU85224.1}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..392
FT /note="acetyl-CoA C-acetyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012830065"
FT DOMAIN 5..262
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 269..390
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 378
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 392 AA; 40495 MW; 5C8CED1B44145FB3 CRC64;
MTKRVAIVAA ARTPIGSFMG ALAAVPATKL GAAAIQGALQ QIQLAPSEVD EVIMGMVVQA
GAGQAPARQA ALYAGLSNEV ACTTVNKVCA SGMKAIMQGA QAIMAGDAQI VVAGGMENMS
QIPHYVSLRN GVKFGPTTMI DGMQKDGLTD AYDQQAMGVC ADLCASEYGF SRGAQDAFAV
ESYQRSTNAW EAGRFDAEVV PVAVPQRKGD PIMVTKDEEF TNVRLDKIPS LNPAFTKDGT
VTAANASTIN DGAAALVLMS EEKANALGLK PLAFIVSYAD AAQEPKWFTT APAKALPKAL
AKAGLSIDDI DYFEFNEAFS VVGLANMQIL GLQADKVNVN GGAVSLGHPL GCSGARIIVT
LINVLKQNQA KYGAAAICNG GGGASAFVIE NV
//
