ID A0A257KCY8_9FLAO Unreviewed; 1018 AA.
AC A0A257KCY8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=CFE24_03315 {ECO:0000313|EMBL:OYU85166.1};
OS Flavobacterium sp. BFFFF2.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2015558 {ECO:0000313|EMBL:OYU85166.1, ECO:0000313|Proteomes:UP000216176};
RN [1] {ECO:0000313|EMBL:OYU85166.1, ECO:0000313|Proteomes:UP000216176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BFFFF2 {ECO:0000313|EMBL:OYU85166.1};
RA Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT formosa and its bacterial cohort.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYU85166.1}.
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DR EMBL; NKJD01000006; OYU85166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A257KCY8; -.
DR Proteomes; UP000216176; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07431; PHP_PolIIIA; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000216176};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..68
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 993..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1018 AA; 117273 MW; 636DB7A084CE3927 CRC64;
MYLNCHSFHS LRFGTIPLDD LVAQAVGYGV TAMALTDLNT VTGIYDFIKA CKKVGIKPLV
GIDFRNNGKQ LYIGLAKNRA GLAEMNRLVT KHHFENTLLP EVAPPFDHVF VIYPFNNVPD
ELKEHEFIGI GADQLPKLYN YVWKRRISKM VILHSVTYRT KKEFNLHKIL RAIDLNIIGS
KLTEADYCKV SEVMIPIDQL LQRFNDFPQI IQNTEAIIAG CHFEYDFYTP KNKKHFTGNS
QDDMELLTKL AYEGMIRRYG AEHAEAKARV EKELKVIHEL AFSGYFLITW DIIQYSLNKG
FLHIGRGSGA NSIIAYCLDI TNICPLELDL YFERFLNVNR KTPPDFDIDW SWRERDTILT
YIFDKYGQDH VAFCGTNVEF KYRSIFREVG KVFGLPKEEL DELAKKPMKK HHKNNVVMMV
QDYGMMLEKY PNQRSMHSCG IIISEEPITH FTALEMPPKG FPIVQFDMHV AEDIGFDKFD
ILSQRGIGHI DDTVKLIREN QGIEVDIRDT SISKDEPTCN ELLSQGKTIG CFYIESPAMR
GLLRRLKCDN YKVLVAASSI IRPGVAQSGM MKEYIFRHNH PDRFEYFHEV FKEQLGETYG
IMVYQEDVIK IALHYGGLPA ADGDILRRAM SGKGRSKAAL QKVKDDFFTS CAKQGHPLAL
SQEIYRQIES FAGYSFCKAH SASYAVESYQ SLYLKTYYPI EFMTAVINNF GGFYRTEVYI
HEARMSGAKI NSPCVNKSDY QTKVYGKNIY LGFQHLKSLE SKTAELITKE RAENGPFNSL
EDFINRIPIG IEAIQILIFI GAFRFTRKPK NELLIIARLI LINFRPENRD LLLLQEPVKE
YQLPVLERSP FEDAFDEIEL LDFPVSVTPF NLLQTRYRGD VMAKDLTKHH KKTVKMLAYL
ISRKHVPTKR GDMFFGTWID AEGAFFDTAH FTDSLQKYPF KGGGCYLLLG QVEVDYHFPT
VTISKMEKMP FIPDPRYSAT DEKRFQTQQQ IREDVSLTHR APYPQEHEIG LPRQKMKP
//
