ID A0A257KG59_9BRAD Unreviewed; 1701 AA.
AC A0A257KG59;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=CFE29_28545 {ECO:0000313|EMBL:OYU86393.1};
OS Bradyrhizobiaceae bacterium PARB1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae.
OX NCBI_TaxID=2015576 {ECO:0000313|EMBL:OYU86393.1, ECO:0000313|Proteomes:UP000216768};
RN [1] {ECO:0000313|EMBL:OYU86393.1, ECO:0000313|Proteomes:UP000216768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PARB1 {ECO:0000313|EMBL:OYU86393.1};
RA Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT formosa and its bacterial cohort.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYU86393.1}.
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DR EMBL; NKIY01000014; OYU86393.1; -; Genomic_DNA.
DR Proteomes; UP000216768; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 863..1130
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT REGION 32..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 985..1037
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1629..1656
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1701 AA; 187509 MW; 0DD372FF4F816D12 CRC64;
MSNDDPFTLD LFGNTALSSG LGLGITAFPS SLEVGGDDDP SPSSPAPARA VTAAGRSPAP
LKGENFYLGD HRGLATSWRE RARDNLAAIC LASEIEQAQR PATTKEQAAL IKFIGFGASD
LANGVFRRPG ETDFRKGWEE IGADLEDAVA TGEYASLARC TQYAHFTPEF IVRAIWAGLQ
RLGWRGGRVL EPGIGTGLFP ALIPEELRTA SHVTGIELDP VTARIVRLLQ PRARIIAGDF
ARTELPAHFD LAIGNPPFSD RTVRSDRALR SMGLRLHDYF IVKALGLLKP GGLAAFVTSH
GTMDKADHGA RAHIAGMADL VGAIRLPEGS FRADAGTDVV VDILFFRKRK DGESDGDLSW
LDLDEVRPAA GDDSALRVNR WFARHPGMVL GTHALTSGPF GETYTCSPRK GENLDAALTT
AVRLLPEAIY DGEPNAIEIE LENDVASDLE RRPDDRQVRE GSYFIGNRHG LMQLVDGAPV
AIHVRKGRSA DGIPDKHVRI IRKLIPIRDA VREVLKAQEC DRPWKPAQVK LRIVWSNFVR
AFGPINFTTV STIEDEETGE VRETHRRPNI QPFLDDPDCW LVASIEDYDL ESNTATPGPI
FTERVIAPPA PPVITSAADA LAVVLNERGH VDPDHVAELL HRDVEDVIAE LGSAIFRDPG
DGSWQTSDAY LSGAVRSKLV MAQAAAALDP AYQRNVTALQ AVQPADLRPS DITARLGAPW
IPAADIVTFV NETMGAEIRI HHMPELASWT VEARQLGYLA AGTSEWGTDR RHAGQLLSDA
LNSSVPQIFD IVKDGDSERR VLNVVDTEAA KEKLQKIKTA FQNWIWSDPD RTDRLARIYN
DRFNNIAPRA FDGSHLQLPG ASGAFSLYGH QKRGIWRIIT AGSTYLAHAV GAGKTMTFAA
AIMEQRRLGL IAKAMLVVPG HCLAQAAREF LALYPNARIL VADETNFTLA KRHRFLSRAA
TATWDAIIIT HSAFRFIAVP SAFEQQMIQD ELELYEELLT KVESDDRVSR KRLERLKEGL
KERLESLSTR KDDLLTMSEI GVDQIIVDEA QEFRKLSFAT NMSTLKGVDP NGSQRAWDLY
VKSRFIETKN PARALILASG TPITNTLGEM FTVQRLLGHA ALRERGLHEF DAWASTFGDA
STELELQPSG KYKPVTRFAQ FVNVPELIAM FRSFADVVMP AYLREYVKVP EISGGKRQIV
AAPPTAAFKA YQRLLDARIT AIEQRDGPPQ PGDDILLSVI TDGRHAAIDL RLVDPGNDNE
VDNKLNLLVA NTFRIWQDTA ANAYVRSDGK PFELTGAAQM IFSDLGTISV EKSRGFSAYR
WIREELIRMG VPASEIAFMQ DYKKSEAKQR LFSDVRSGKV RVLIGSSDTM GTGVNAQLRL
KALHHLDVPW LPSQIEQREG RIVRQGNQHD VVDIFAYATL GSLDATMWQN NERKARFIAA
ALSGDTSIRR LEDMGEGQAN QFAMAKAIAS GDQRLMQKAG LEAEIARLDR LRAAHVDDQH
AIRRQIRDAE REIELSTRRI GEIGQDIERL VPTAGDAFTM TVMGKAHDER KLAGRALMKE
ILTLVQLQHE GEVVIVSIGG FDLEFSGERF GKDGFHFTTT LMRTGADYEI GLPVTVTPIG
AVARVEHALA GFDDEQQNYR RRLAEARKRL SSYQSRIGEE FAFAAEFKMK REQLAEIDAD
LARDTDAAAD GNAQPADRVA A
//
