ID A0A257LHN6_9BACT Unreviewed; 712 AA.
AC A0A257LHN6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Penicillin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFE26_26280 {ECO:0000313|EMBL:OYU99122.1};
OS Verrucomicrobiales bacterium VVV1.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales.
OX NCBI_TaxID=2015575 {ECO:0000313|EMBL:OYU99122.1, ECO:0000313|Proteomes:UP000216473};
RN [1] {ECO:0000313|EMBL:OYU99122.1, ECO:0000313|Proteomes:UP000216473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VVV1 {ECO:0000313|EMBL:OYU99122.1};
RA Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT formosa and its bacterial cohort.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYU99122.1}.
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DR EMBL; NKJB01001874; OYU99122.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A257LHN6; -.
DR Proteomes; UP000216473; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000216473};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..712
FT /note="Penicillin-binding protein 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012513822"
FT DOMAIN 62..240
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 275..603
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 638..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 77558 MW; 37872517FBB23279 CRC64;
MRRSRRQIAT RFHGLAGLFL AGSSLAAQEI PPVAASNPPS AGRSANEGSI LTQKNARTIS
LKIPAPRGQI VDREGECLAQ NTIAYQIGLQ FKQFENADRE YVLSWAKSRI ELARILVKST
RTPTDDEIYD HYKNRRWLPL LISDQVSAKD AKAMETKLGT GLILHPIYRR YYPEEGIAAH
ILGYTGSVGK LPTGPINFNE PLWEESEGRA GLEKIYDRQL QGDPGGKRLL FDEAGNKLLE
EQTKRPMPGG TVVTTLNLKW QKQAEKVLRK GCKRGAFVVI DVLTGEVLVM ASRPTFDLNS
FIPGIGEKEY KALNDDPGQP LFGRAFQSAY PPASTFKPIV ALAALNNGTV TEDTEIDCPA
SIRIGNHTFN NWSKKSEGSI DVKRAIARSC NPWFYQVGID VGQGAFLGLA RRLGYGEKTG
LPLVGETTGL VPTNEWMLQH EKRRINDGDT ANLSIGQGVL LSSPLQVAQA MAGIANGGAL
PKLQLVRQIQ DARGRVIEAT RPEKRVWLGV DAKAIETVRE GMRDVVNSGD GPGRSAGLSF
TELCGKTGTA QWGPPSKEQR LAWFAGFFPF ESPRFAFAVL YEGSPGETVS GGRMAGPMVR
DFFEPLKDEI KVIIAPPPKA LMVKEDAGDD QEGVLKAQPV DEGNSDEPAP PKALPVNPDD
LPAEEPIRSC QKERGRLRPQ QAAESEGPSP IPSAAAVAQS LERIHRGLTQ PG
//
