ID A0A257M5Z6_9BACT Unreviewed; 864 AA.
AC A0A257M5Z6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=CFE26_03290 {ECO:0000313|EMBL:OYV07002.1};
OS Verrucomicrobiales bacterium VVV1.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales.
OX NCBI_TaxID=2015575 {ECO:0000313|EMBL:OYV07002.1, ECO:0000313|Proteomes:UP000216473};
RN [1] {ECO:0000313|EMBL:OYV07002.1, ECO:0000313|Proteomes:UP000216473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VVV1 {ECO:0000313|EMBL:OYV07002.1};
RA Kojadinovic M., Villain A., Puppo C., Fon Sing S., Prioretti L., Hubert P.,
RA Gregori G., Zhang Y., Sassi J.-F., Claverie J.-M., Blanc G., Gontero B.;
RT "A metagenomic investigation of the 'star' freshwater diatom Asterionella
RT formosa and its bacterial cohort.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYV07002.1}.
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DR EMBL; NKJB01000064; OYV07002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A257M5Z6; -.
DR Proteomes; UP000216473; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013229; PEGA.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR005532; SUMF_dom.
DR InterPro; IPR042095; SUMF_sf.
DR PANTHER; PTHR23150:SF19; FORMYLGLYCINE-GENERATING ENZYME; 1.
DR PANTHER; PTHR23150; SULFATASE MODIFYING FACTOR 1, 2; 1.
DR Pfam; PF03781; FGE-sulfatase; 1.
DR Pfam; PF08308; PEGA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000216473};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..298
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 864 AA; 95313 MW; BD89E497F8F46B94 CRC64;
MPPIKNRPDP VVPDHEVLRK IGGGAYGEVW LARGVTGALR AVKVVWREDF DDARGFEREF
EGILKFEPIS RTHPGLVNIL HVGRSPDGTS FYYYVMELGD DVRTGAEINA IEYEPRTLRA
DTKLACGIRL ETNLCIDVGL RLAEALDHLH ELGLAHRDVK PANVIFVNGK AKLADIGLVA
TRGQRTFVGT EGFVPPEGPG SAPADVYSLG KVLYEIATGK DRLDFPELPD EAPPPEEKKR
WLELNRIICD ICDPQLSRRK ITTAAELADA LRRLQRGKRR RQTGLAAWMT AIVLGVFIAL
GTWEALKDSP VMGWFSTPDP IVTVPDVVEK FGQIRVVSYP EGAEVIGPDE QWLGVTPLTL
KAAVGSDVEY LIRKPGFRPM TVRGKVPPSA VNEPLPLGSE LGIFSPPEIG ASWEDHQGGS
YQPVANEHLA SLLVSEASWR RFVNVTKRKI EAVEFFPISQ NGRPIQSVLA SKGEANAYCA
WLREAAIKEG YLTADHEMLA KFDDGFNDPA ASERARNEGL KPFRILVRLI PYGRIILTTT
PPGAAVYLNN GPLVGDTTPL EIDKVKPGPV TLTIVLDGYK PLTLNLEMKP DDLITLDKPL
QENQGVRFDK PWKNGLGMKF VPYGSEGELM VSIWETRISD YDAFVADKNS GAKPLRKPDF
AQTKDHPVIY VTRDDARNFC TWLTKRERTE ERISVAHTYR LLTDLEWSRI AGIAEVAGQG
PGWRDIRKPL VFQWGSSWPP PANYANLADS AAAKAPGVPA NRTIEGYDDQ FETTAPVGSF
PPNAAGLHDL CGNVHEWVND DYTTAQPGHA TYGVLRGGGW NSFQPDNLYT GARNAVPPNR
SDNIYGFRVV LAKVPSKPDN ITDP
//
