ID A0A258C6A3_9GAMM Unreviewed; 489 AA.
AC A0A258C6A3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=aconitate hydratase {ECO:0000256|ARBA:ARBA00012926};
DE EC=4.2.1.3 {ECO:0000256|ARBA:ARBA00012926};
DE AltName: Full=Iron-responsive protein-like {ECO:0000256|ARBA:ARBA00031977};
DE AltName: Full=RNA-binding protein {ECO:0000256|ARBA:ARBA00031081};
DE Flags: Fragment;
GN ORFNames=B7Z23_08740 {ECO:0000313|EMBL:OYW91090.1};
OS Pseudomonadales bacterium 32-61-5.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales.
OX NCBI_TaxID=1970544 {ECO:0000313|EMBL:OYW91090.1, ECO:0000313|Proteomes:UP000215582};
RN [1] {ECO:0000313|EMBL:OYW91090.1, ECO:0000313|Proteomes:UP000215582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=32-61-5 {ECO:0000313|EMBL:OYW91090.1};
RA Kantor R.S., Colenbrander Nelson T., Marshall S., Bennett D., Apte S.,
RA Camacho D., Thomas B.C., Warren L.A., Banfield J.F.;
RT "Lifting the veil on microbial sulfur biogeochemistry in mining
RT wastewaters.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023501};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 2/2. {ECO:0000256|ARBA:ARBA00004717}.
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYW91090.1}.
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DR EMBL; NCDF01000572; OYW91090.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A258C6A3; -.
DR UniPathway; UPA00223; UER00718.
DR Proteomes; UP000215582; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd01581; AcnB; 1.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015929; Aconitase_B_swivel.
DR InterPro; IPR015932; Aconitase_dom2.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF4; ACONITATE HYDRATASE B; 1.
DR Pfam; PF00330; Aconitase; 2.
DR Pfam; PF06434; Aconitase_2_N; 1.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00450; ACONITASE_1; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 3..69
FT /note="Aconitase B swivel"
FT /evidence="ECO:0000259|Pfam:PF06434"
FT DOMAIN 149..385
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 388..488
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OYW91090.1"
FT NON_TER 489
FT /evidence="ECO:0000313|EMBL:OYW91090.1"
SQ SEQUENCE 489 AA; 52762 MW; 91E00285AB238A00 CRC64;
GEVRRHGSDE LVTTFELKTD VLLDEVRAGG RIPLIIGRGL TDKARAELGL GPANLFKMPV
APADSGKGFT LAQKMVGRAC GLPEGKGVRP GTYCEPKMTT VGSQDTTGPM TRDELKDLAC
LGFSADLVMQ SFCHTAAYPK PIDVNTHHTL PDFIQNRGGV SLRPGDGIIH SWLNRMLLPD
TVGTGGDSHT RFPMGISFPA GSGLVAFAAA TGVMPLDMPE SVLVRFKGEM QPGITLRDLV
HAIPYYAIQE GMLTVEKKGK KNIFSGRILE IEGLNNLTVE QAFELSDASA ERSAAGCTIK
LPEEAIAEYL KSNITLLRWM ISEGYGDPRT LERRAQAMEA WLAKPNLLEA DKDAEYAAVI
EIDLADVKEP VLCAPNDPDD ARLLSTVAGE KIDEVFIGSC MTNIGHFRAA GKLLEKVKGG
IPTRLWLAPP TKMDAHQLTE EGYYGIYGKA GARMEMPGCS LCMGNQARVQ TGSTVVSTST
RNFPNRLGD
//