ID A0A258TLW2_9PROT Unreviewed; 753 AA.
AC A0A258TLW2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Heterodisulfide reductase {ECO:0000313|EMBL:OYY92405.1};
GN ORFNames=B7Y41_15895 {ECO:0000313|EMBL:OYY92405.1};
OS Hydrogenophilales bacterium 28-61-23.
OC Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales.
OX NCBI_TaxID=1970530 {ECO:0000313|EMBL:OYY92405.1, ECO:0000313|Proteomes:UP000215898};
RN [1] {ECO:0000313|EMBL:OYY92405.1, ECO:0000313|Proteomes:UP000215898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28-61-23 {ECO:0000313|EMBL:OYY92405.1};
RA Kantor R.S., Colenbrander Nelson T., Marshall S., Bennett D., Apte S.,
RA Camacho D., Thomas B.C., Warren L.A., Banfield J.F.;
RT "Lifting the veil on microbial sulfur biogeochemistry in mining
RT wastewaters.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the HdrA family.
CC {ECO:0000256|ARBA:ARBA00006561}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OYY92405.1}.
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DR EMBL; NCGJ01000021; OYY92405.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A258TLW2; -.
DR Proteomes; UP000215898; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR039650; HdrA-like.
DR InterPro; IPR003813; MvhD/FlpD.
DR PANTHER; PTHR43498:SF1; COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A; 1.
DR PANTHER; PTHR43498; FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A; 1.
DR Pfam; PF13187; Fer4_9; 1.
DR Pfam; PF02662; FlpD; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 538..567
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 568..597
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 753 AA; 81250 MW; 9DDCB71CFC77CFB7 CRC64;
MAENKTAAYI CKGCEIDKRV DVAGLVKAAT KSGKMNLVRE HDFLCSAEGV AMIKNDIENE
GVTHAALCAC SRRAKTEAFN FPTIAMSRGN LREGVIWIRP DTDEARETTQ EMAEDYVRMA
CAEVKAMTVP PGNQKTGSVK TLLVVGGGMS GMTSALESSK AGYKVVLVEK SAALGGWAAK
LYKRVPTREP FKAPEDNGVA DMVARIDADS NIKVYLNATI AKTDGAPGRF KVDIAIESGS
MAQEDVGAII QATGFTLYDA NKLPEFGYGK TPNVVDQAGL EALAKAAAAE GKPICRPSDG
QPVKSVVFVQ CAGQRDPSGT HLQYCSGFCC NTSIKQATYF KDSNPDIDTV VLFTDLRTPG
NGEDFYRAAQ NRGVVFSKGV VSQVTPNGNA CTVKFKDLIL NEDTEAQADL VVLATGMVPV
SGVNIDAVAA APVEAEAAVE GEAPKEVVAT IAPESILNLT YRQGPDMPQF KHGFTDSHFI
CFPYETRRTG IYTAGPVRRP MDILQAQEDA TGAAMKAIQA MENAGLGKAA HPRAGDLSFP
TVRLEGCTQC KRCTVECPFG AIDEDEKRFP LFNESRCRRC GTCMGACPVR VISFENYSVN
TVGAQIKAVD VPDEFSEKPR ILILACENDA YPALDMAGMN RHEYDPYVRV IPVRCLGSVN
TIWITDALNG GYDGVMLMGC KHGEDYQCHF VKGSELGRYR LSKVGDTLKG MNLETDRVKD
LEVAITDMAT LPQKINEYAA LIKSFPPSPF KGF
//
