ID   A0A259F501_9PROT        Unreviewed;       781 AA.
AC   A0A259F501;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:OZA33608.1};
GN   ORFNames=B7X82_08025 {ECO:0000313|EMBL:OZA33608.1};
OS   Hydrogenophilales bacterium 17-64-65.
OC   Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales.
OX   NCBI_TaxID=1970528 {ECO:0000313|EMBL:OZA33608.1, ECO:0000313|Proteomes:UP000216509};
RN   [1] {ECO:0000313|EMBL:OZA33608.1, ECO:0000313|Proteomes:UP000216509}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17-64-65 {ECO:0000313|EMBL:OZA33608.1};
RA   Kantor R.S., Colenbrander Nelson T., Marshall S., Bennett D., Apte S.,
RA   Camacho D., Thomas B.C., Warren L.A., Banfield J.F.;
RT   "Lifting the veil on microbial sulfur biogeochemistry in mining
RT   wastewaters.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZA33608.1}.
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DR   EMBL; NCIQ01000010; OZA33608.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A259F501; -.
DR   Proteomes; UP000216509; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        27..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        53..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        254..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        426..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        464..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        493..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          528..721
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   781 AA;  85808 MW;  1AC99E3E97359621 CRC64;
     MRLTLIAFCL GVWWLQQQPE LPPARWLWLL PLLLALLWLP VFSHAVAEFT RRLGIALLCV
     ALGFAWAAGR ADARLAERLP APWQGVDIAL VGVIADLPHA NARGERFVFD VEQVTPPHAP
     VLRRVQLTRY WPRGSSDRVA RMQAGERWQL TVRLKMPYGT SNPHGFDLEA WMLEHGINAS
     GYVRETPAPQ RVAARAATPA AWIAATRATV RQRIFTTLGD APYAGVIAAL VVGDQRSIPH
     GQWRAFTRTG VNHLLSISGL HVTMIATLAG WLMASGWRRL PRQAERLPAR QAGLIAAVLA
     ALAYAVLAGF QVPAQRTLFM LIVLALAFWG RRQPRPFTAL IVALFVVLLV DPWAVLSAGF
     WLSFGAMAAI LWVTFGRVAL PDKLRGWVTV QGAVTLALAP VLFLLFQQVS LISPLANAVA
     IPLVSWLVTP LALLGVLIPS LWQVAAWLMA WLGAGLDWAS SLPLAVMTLP APGWGAAALA
     LVGTVWLLLP RGFPLRVLGL LLWLPLLFPL RDAIAPDHFR AEAIDVGQGT AVLIRTANHA
     LLYDTGASFA DSDSGERIVV PYLRAAGIGR LSGLIVSHDD NDHSGGLRSV LRDIPTDWLL
     HGMPASSPLL DDVSPARSCV RGQHWNWDGV QFEILNPRPA AYAESRRRDN DFSCVLRVSS
     ARHSLLLTGD GERQTELELL ESGQLASVDV LFAGHHGSRT SSIPEFVAAT RPEFVVFTLG
     HRNRYGHPHP HVVARFREIN ARLLRSDAAG MIRLDFGEAG VDASQYRPTY RRYWQTQFTQ
     P
//