ID   A0A259FFY1_9PROT        Unreviewed;       511 AA.
AC   A0A259FFY1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Exosortase A {ECO:0000313|EMBL:OZA37311.1};
GN   ORFNames=B7X87_11350 {ECO:0000313|EMBL:OZA37311.1};
OS   Hydrogenophilales bacterium 17-64-34.
OC   Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales.
OX   NCBI_TaxID=1970527 {ECO:0000313|EMBL:OZA37311.1, ECO:0000313|Proteomes:UP000216129};
RN   [1] {ECO:0000313|EMBL:OZA37311.1, ECO:0000313|Proteomes:UP000216129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17-64-34 {ECO:0000313|EMBL:OZA37311.1};
RA   Kantor R.S., Colenbrander Nelson T., Marshall S., Bennett D., Apte S.,
RA   Camacho D., Thomas B.C., Warren L.A., Banfield J.F.;
RT   "Lifting the veil on microbial sulfur biogeochemistry in mining
RT   wastewaters.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZA37311.1}.
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DR   EMBL; NCIL01000009; OZA37311.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A259FFY1; -.
DR   Proteomes; UP000216129; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR013426; EpsH-like.
DR   InterPro; IPR026392; Exo/Archaeosortase_dom.
DR   InterPro; IPR019127; Exosortase.
DR   InterPro; IPR017540; Exosortase-1.
DR   InterPro; IPR014263; Methanolan_biosynth_EpsI.
DR   NCBIfam; TIGR02602; 8TM_EpsH; 1.
DR   NCBIfam; TIGR02914; EpsI_fam; 1.
DR   NCBIfam; TIGR04178; exo_archaeo; 1.
DR   NCBIfam; TIGR03109; exosortase_1; 1.
DR   Pfam; PF11984; DUF3485; 1.
DR   Pfam; PF09721; Exosortase_EpsH; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        46..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          306..503
FT                   /note="Methanolan biosynthesis EpsI"
FT                   /evidence="ECO:0000259|Pfam:PF11984"
SQ   SEQUENCE   511 AA;  56085 MW;  B135D75C6AE6C947 CRC64;
     MIAPVSSGAS GWQRAGLTVG AAILLAFVLF WPTFMSMVEV WERSETFAHG YAIFPISLWL
     IWRRRGVLAR MTPRADARGL AAMALAAAGW LLADAGSVNV VAQYAFIALL ISTAWAILGW
     AVVWALFFPL MFLFFAVPVG EFLIQPLMGV TADFTVAMLQ FTGIPVYREG TFFSIPSGDW
     SVVEGCSGLR YLIASVTLGV LYAYLTYRSW KRRLLFSIAA VIVPIFANSG RAYMIVMIAH
     LSDMKLALGV DHYIYGWVFF GFVMLLLFWI GSFWREDDQP EPALPAEPGT LSRTARLGVL
     PVAGAAALLV AVAPLYATWL ASRPLPAMPA LTVAAAAGWQ PAPSFTPWVP HWVGADRQVR
     VPFVREQQTV MLEINYYAAQ RQDAELVNSQ NFMIRQKDPQ WSNVGESLTT VDIAGQPHPV
     RQAKLRGTDG QRLLVWQWNV VNGRPTVNDL TTKLVLAFDR VRGARDDGAS VLIATPYDDV
     ASIDTARATL ARFAADMQPA IARALAAVEA P
//