ID   A0A259U6R4_9FIRM        Unreviewed;      1061 AA.
AC   A0A259U6R4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=DNA-directed RNA polymerase subunit alpha {ECO:0000313|EMBL:OZC13664.1};
DE            EC=2.7.7.6 {ECO:0000313|EMBL:OZC13664.1};
GN   Name=rpoA_2 {ECO:0000313|EMBL:OZC13664.1};
GN   ORFNames=SPACI_56450 {ECO:0000313|EMBL:OZC13664.1};
OS   Sporomusa acidovorans DSM 3132.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=1123286 {ECO:0000313|EMBL:OZC13664.1, ECO:0000313|Proteomes:UP000216052};
RN   [1] {ECO:0000313|EMBL:OZC13664.1, ECO:0000313|Proteomes:UP000216052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 3132 {ECO:0000313|EMBL:OZC13664.1,
RC   ECO:0000313|Proteomes:UP000216052};
RA   Poehlein A., Daniel R.;
RT   "Genome sequence of Sporomusa acidovorans DSM 3132.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZC13664.1}.
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DR   EMBL; LSLL01000153; OZC13664.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A259U6R4; -.
DR   STRING; 112900.SAMN04488499_10247; -.
DR   Proteomes; UP000216052; Unassembled WGS sequence.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR011260; RNAP_asu_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03118; RNA_pol_A_CTD; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   SUPFAM; SSF47789; C-terminal domain of RNA polymerase alpha subunit; 1.
DR   SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE   4: Predicted;
KW   DNA-directed RNA polymerase {ECO:0000313|EMBL:OZC13664.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:OZC13664.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000216052};
KW   Transcription {ECO:0000313|EMBL:OZC13664.1};
KW   Transferase {ECO:0000313|EMBL:OZC13664.1}.
FT   DOMAIN          163..214
FT                   /note="RNA polymerase alpha subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03118"
FT   DOMAIN          415..448
FT                   /note="RNA polymerase sigma-70 region 4"
FT                   /evidence="ECO:0000259|Pfam:PF04545"
SQ   SEQUENCE   1061 AA;  121558 MW;  052CF36F648271E8 CRC64;
     MDAKIKIAEA FSQGEYASFL EYCNVCNYIF LDELTSVDFV AFKAKYNADV SFVKQLKRNV
     YDFESGVIPL HQDGIPKPVA LEAAATFSTD EKVDLLSDDN GTFNSIIEGK PHYEEENSDF
     TITNDKVKFT ATVEKVMVGT LEPLLDSVHP VSKAYDRVPW VDSIHGLNLS ARATNALIKG
     GIKTVLQLLE LDREKLSQIR NLGAKSIDEI LAKIVELERQ HFSVSLVDDF DSAKGKIFLS
     PECRSIIETI LLGENDDGAR KNLSSEEQKI VKNVVNAIDC IGCEFSLEIY TNSSRVIPLI
     ASLEEFSTAY EREKKLFEVY DLIPYYRRSY MLSNYIKAFT STGAKTAHAV LKPFLQPQIK
     VSDLKKLFSE VCKEKNSEAA MSVLLQLLQT DFRQVLTTAL GNMIPKYEKP FSILCRRCAG
     LSLESIAIEF GLTRERIRQI EKKAMTVLHA NIAQTGIDPL MFICADRNGD TVLTIQEITD
     YIGDSSKTEL FKYFLQKYNS SNSFVYDSDR KLFHLKNMVY NADRVEQFVS DLPQIIFCNK
     LATLLSSVSS QVGVPLEILQ TEFKRKYSFS GQVWYRGRLT VSLMCEVILK TYYPAGIKLY
     DEDEENRFRE KVKEVFGNVK FSNNIRAFCA RLADVAVLCD RGMYIHPSYI QIPDGLVQKI
     DDYISGSERI AISFHELFER FKEELLLSSN VSNHYFLQGI LHYRLKDKYY FTRDLISKEK
     DAKFGAELEV FIRERGEVHK NEILSEFPGI SDIMLSMKVN GSKSIIGLDN GQYMHSDLLN
     LQEEDYTIRE IIETEAKNLP VSSRKLLDLL WITHADFLTR NEVSTHSKLF GILQYMFEDE
     FSFSRPYIAK LGTTDEITNL TVIKQHLQDY DRLSVSELMG ICTENHLQFL SIRGLIRQLN
     NDFLRINSEM LIRIDDSVLT DETLHEIENM ILEGFSCKGY IVASRIDNYI FYPDIGVSWN
     AFLLRSIVEK YFSEEIRIVD MPTTDTFAMN TVFVDPTMDV DNYEDLLRSV LKSEHNRDPF
     LSIDDVLNWL QGEKLILGEP PKCLTDGRVV CRDEYREIII K
//