ID   A0A259UZ21_9FIRM        Unreviewed;       529 AA.
AC   A0A259UZ21;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   Name=glcA_1 {ECO:0000313|EMBL:OZC23248.1};
GN   ORFNames=SPSIL_03010 {ECO:0000313|EMBL:OZC23248.1};
OS   Sporomusa silvacetica DSM 10669.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=1123289 {ECO:0000313|EMBL:OZC23248.1, ECO:0000313|Proteomes:UP000216752};
RN   [1] {ECO:0000313|EMBL:OZC23248.1, ECO:0000313|Proteomes:UP000216752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10669 {ECO:0000313|EMBL:OZC23248.1,
RC   ECO:0000313|Proteomes:UP000216752};
RA   Poehlein A., Daniel R.;
RT   "Genome sequence of Sporomusa silvacetica DSM 10669.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZC23248.1}.
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DR   EMBL; LSLK01000029; OZC23248.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A259UZ21; -.
DR   OrthoDB; 9761056at2; -.
DR   Proteomes; UP000216752; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   PANTHER; PTHR30003:SF2; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000216752};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        31..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        58..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        100..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        185..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        239..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        334..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        374..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        415..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        457..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        502..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   529 AA;  57419 MW;  4EF8DBEE85329AD9 CRC64;
     METLIFTLLP IVVILAMLII WKQAADVSGI VGWLAISVVA YFVFQTSIEV ILRSTVAGFI
     RSFAVSLIVA TSLLQMAFME QTGALKRIII FIKTIASENR GIQIMLINIG FGTLMVSVGA
     TPVSLLPPIL LAMGYSTTVA IALPAIGYDS LCTYALLGAP IVVFVDVANS FFGKGNEISL
     AQAGMAFYMF LPVVSTLIGL CMLWIVGQWR GIKEGLIPCL ITGTIIGIVS YFTNKYDNLV
     VLTGVLCGIA VIIAMVMLLV ISGKNVIDKS KLTAEEIAYE RQYSLWRALT PWIILIVLIL
     LLNIPKDIFN FLYRTLKLPI TGITANGSAI DTRALWNAYT WIFISTIMSI PFIRPTSQQI
     KKTLAIWWKR APRPVFSAAI FFSIGEIMNM SGYSMVTGQF ETASMVKVLA DYSAIYFHDT
     YGAIVAFIGL FGGFITGSEA STIAMFAKYT LTTAKNLNMT LLGSIIITAG LAFGGGLASV
     ISPAKLQNAA ASIDKLGQEN QIIRTAFIFS LIITLVTSLF VLLLLKIAV
//