ID A0A260X670_9NOCA Unreviewed; 3459 AA.
AC A0A260X670;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CH292_03135 {ECO:0000313|EMBL:OZF56640.1};
OS Rhodococcus sp. 14-2470-1a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=2023150 {ECO:0000313|EMBL:OZF56640.1, ECO:0000313|Proteomes:UP000215821};
RN [1] {ECO:0000313|Proteomes:UP000215821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14-2470-1a {ECO:0000313|Proteomes:UP000215821};
RA Savory E.A., Fuller S.J., Weisberg A.J., Thomas W.J., Gordon M.I.,
RA Stevens D.M., Creason A.L., Belcher M.S., Wiseman M., Putnam M.L.,
RA Grunwald N.J., Chang J.H.;
RT "Evolutionary transitions between beneficial and phytopathogenic
RT Rhodococcus challenge disease management.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZF56640.1}.
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DR EMBL; NPFZ01000005; OZF56640.1; -; Genomic_DNA.
DR Proteomes; UP000215821; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 47..473
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1633..1708
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1726..2139
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3333..3409
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3459 AA; 359133 MW; C681956A16298993 CRC64;
MTDSAASGSR SPEREAEDQK ILRYLKKVTA ELQRTRERLR AVETEGAEPI AVVATGCRFA
GGIDSPEALW DKVMRGEDVI GDFPTDRGWD LDAVYDPDPE SAGTSYVRRG CFIDAVGDFD
PAHFGISPRE AELMDPQQRL LLEVSWEALE RGGIAPGSLR GGQVGVYVGT NGQDYRGLLD
RIPAERDSAL GTGTLAAVIS GRISYVLGLE GPAVTVDTAC SSALVGMHLA ATALRNRECS
LALAGGATVM TTPDSFIAFS RQRGLAIDGR CKAFSDDADG TGWGEGVGMI VLERLSDAQR
NGHPVLAVLA GSAINSDGAS NGLTAPNGPS QQRVIRSALT AAGLSGADVD VLEAHGTGTT
LGDPIEAQAL MSTYGRTRGP SGPLLLGSIK SNIGHTQAAA GAAGVIKMVT ALGKGIVPAT
LHVSEPSSTI DWTAGAVELV TETTHWPAVQ RVRRAGVSSF GASGTNAHVI LEQAPAPEAP
DERTPGPLGS VRLPLLVSGR TAAARDDQAR SIAALLEEPG IEHDAVAGAL ALTRTHLRHR
AAMVGRTPAD SARGLKDTSD TEVSVLGIAG DRIEPVFVFP GQGSQWRSMA TELMSSSPVF
AARMAECAQA CSSYVEWDLL EELSGPQDRV DVVQPLLWAV MVSLAHTWQA CGVSPAAVIG
HSQGEIAAAV VAGALSLDDG ARVVTLRSRA IARDLAGRGG MMSIGESAET VRRRLTAHPE
LSVAAINGAR SVVVSGDVAA LDALTEELVA DDVRIKRLPV DYASHSAHVD SLRATLDEVL
SGLSPRSSEI PFYSTVTGEP IDTAVLDAKY WFTNLRGTVR FAETVERVIA DGFGLFVESS
PHPVLTLGIA ETADSADGPV VATVPSLRRD DGGPERFVAS LAEAHVHGAA VDWKTVMGSG
LAPVALPTYP FQRQMYWPEA GWSVGDVRSA GVDATGHRLL GGAVVQADGG GAVFTGRLST
ATHPWLADHA LGDVVIFPGT GHLELVAAAA ERLGCGVVED LTLGAPLVIP DGAALGIQVI
FGAPDDTGRR HVGVYSTSDD TDLGDRSWQT HATGTVGTGA GDVFVGNRLD SWPPPGAEAV
DVADLYAGYA EANLHYGPAF RAVTAAWRVG DDLYATVNSP VDVDGVDLHP AVADAALHAI
GLTSIAGDDA LLPFSWSDVR IHAVGAHDVR VRVHPVGDFS VSVDIADFSG APVASIGELV
VRAVSADALP VHRKNAGDLY QVVEVALEDN ATDLEAAEST VVEALSGSTA TEVEAALVLL
VSELREALDS DAETVAVVVP GDPAGAAAAG LVRAAAAEEP DRIVLVTATG DIDVEDAVTR
ARAAGEPHVV VRGSEVFTPR LVRADTAVSD DGLRTDGTVL ITGASGVLAG ELARHLVHGN
GIRHLTLLSR SVISDDLIDE LTSAGAEISQ VRCDVTDAKA LSAVFDALPA ERPLRGVIHT
AGVLADGTFG ALTPERLGVV LAPKVHGAWN LHELTRERDL DVFVMFSSTA GVLGAPGQAN
YSAANAYLDA LAELRRGVGL PAQSLAWGLW AQGSGMTGSM DGTDRSRLTR GGITPLATDD
AFALFDRGLR SPNLAAVVAA DFDLAGMRSR GERPDPAFRS LVTVRRTSAA AQVVDENAWR
SELSAADPAQ RERMVTDLVR GRIATILGHR SVDGVPADRP FKELGFDSLA AVELRNALSA
VTGLRLPATL VFDHPTPVVL ARKLIGDLGD TVTSTPQKRA PAVSSDEPVA IIGMACRYPG
GVESPDDLWD LVASGRDVVG GFPDDRGWDL DRLYDPTLDR PGTSYSRQGS FLDGAGDFDA
DLFGIDPLEA NSLDPQVRQL LETSRTALEH AAIDPTSLAG TDTGTYVGLM YHDYAGAYGT
GSVVSGRVAY ELGLEGPTMT VDTACSSSLV ALHLAAQALR AGECGVALAG GVTVMATPGI
FVEFSRQRGL SPDGRCRSFA DSANGTGFSE GVGVLVLERL SDARRNGRNI LAVLRGSAVN
QDGASNGPTA PNGPAQQRVI RRALDSAGLT TADVDVVEAH GTGTTLGDPI EAQALIDTYG
RGRATEDPLW LGSIKSNIGH SQAAAGVAGV IKMVQALRHR EMPATLHVDG TPSRHIDWED
SGVALLADGR QWPERDRPLR AAVSSFGLSG TNAHVVLEAA PATERVVPQA YASIPWLLSG
TSAQSLRTQA AALAAGLAAN QDVDAVGTAR TLATGRAQLG HRAALVGSDV SELRTALTAL
VAGDASANAM TGTARSGRTA FLFTGQGAQR PGMGSEAAAA HSAFERALAE VCSYADPLLD
TPLREAIASP ELVGRTEYTQ PALFAVQIAT YRFLTSLGVQ PDALVGHSIG EIAVAHVAGV
LDLPSAVRLV CARGRLMQAL PDGGAMVAIG APVDEVRPYL TSDVGLAAVN GPAAVVVSGT
ESAVEAIAAR FERTTRLRVS HAFHSPSMLP MIDEFRTVVE DLEFGSPTIP IVSTVTGEPV
TDGMADPEYW VRHVSGTVRF EDAVNTLCNR AVARMVEIGP GSTLSSLASS CVADADAPPE
VFPTLRSGRP EPEALSVALA RIHVSGGIVD WSSLLGSGAP AADLPTYVYS HRRYWINSDV
VEHDRSAHPI LGGAVEIAGT GTTLYSSEIS VATHPWLADH RMGTTVVVPG TVFAEIAVVT
ASSVGSSTVR ELTVTTPLVL SDTGSRTLQA SVSGADREGV RELSIYSAER AGGEWTLHAV
ATLADDTLAD DTVALDPDSD QWPSSDAHDV TAVDVDALYA AASTAGVDYG RTFRGLTAVW
VRGDDVYAEV SADALMSGGA TGSGHVLHPA FFDAVLQPVT ARQGAGDSVV MPFSWSGIRI
TPSRSNVVRV RLAATGSDTV RVTAVDDRGL RVVDIESLTL REVSVRRFSA LGVADGLSVI
ERIPLSTSGS PTATHWTVVS SDPVAAAALA DEAATVRTAT DIADAASVAT DVVVVGAWGD
GGLDAHAGSS ARRRLHDVAE HIRRWSSEPA LAATTLVVWT AGVADSAVKG LVRSAASENA
GTIVLVDALP GVDAPSALRA LPAALATGES DIVIGTDGIY APRLTAAPAF DGDPQQWPDT
VLVTGGTGAV GGTVAKHLVR THAVGHVVLM SRRGLGADGA PELVSAIEDA GGRVTVVAGD
IADEATVRAV FDAHPIRGVV HAAGVLDDGL LETMTEDRTD AVARPKIDAA LVLHAVTIDH
AVEKFVLFSS TAGILGSPGQ SNYAAANTFL DGLAQHRQTL GMAATSLVWG RWSGGGGMAD
RLDDSGARRL AESGIVGMSD EDALALFDAA VDRGDAVVVP ARFDVAGLTA RFDASPASVA
PVLRGLLRRT TRAASPTDRG AELRASLAEL SVSEQSDLVD ALVHDHTSAV LGVTDIDMDS
AFGDLGFDSL AAVEFRNRLV EATGLRLPAT VVFDHPSPAV LAAHLLTELV PQVSVRETVI
RERAVDIGSV TDDDIDALDT DALISRALGS SDESDPSAE
//
