ID A0A261BLS2_9PELO Unreviewed; 704 AA.
AC A0A261BLS2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
DE Flags: Fragment;
GN ORFNames=FL83_14983 {ECO:0000313|EMBL:OZG10690.1};
OS Caenorhabditis latens.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1503980 {ECO:0000313|EMBL:OZG10690.1, ECO:0000313|Proteomes:UP000216463};
RN [1] {ECO:0000313|EMBL:OZG10690.1, ECO:0000313|Proteomes:UP000216463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX534 {ECO:0000313|EMBL:OZG10690.1,
RC ECO:0000313|Proteomes:UP000216463};
RA Fierst J.L.;
RT "Caenorhabditis latens genome sequence.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZG10690.1}.
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DR EMBL; NIPN01000118; OZG10690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A261BLS2; -.
DR STRING; 1503980.A0A261BLS2; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000216463; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000216463};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..704
FT /note="heparosan-N-sulfate-glucuronate 5-epimerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012514731"
FT TRANSMEM 501..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 395..482
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OZG10690.1"
SQ SEQUENCE 704 AA; 81100 MW; 80AFD5F0DF2D79A1 CRC64;
MKCLRWRSNR HRFYMFLACA SLFLLCKHYS SPNEKADEEN EYLIPVDEHE KEKKIECEPP
GAVESKCTVD NGKAMRCWKD EEEVYFPTSY LKKRFDMTGK FGKDGSTFEL YTSYAKMRTP
ESIYEPLGPF GHFATYSVET RDRVRYVPMS TQWDPTPYYY PIQIAQYGLQ HYNSNSNKTE
DKREVLVGVK SNEWKGAAGM HETTERLFFN DEEKGKVVNI SAGYALANAG AYVYLDKSPD
LHVVSFDWKP YDGNASFTVL AKMKQDDLLV LINYVFSEGN GKCVWQEEER SYDDDTIVQK
PKKDGQVSYS YSYTGSSQYG EWSKVTRDIL VDVSRALSSG DNRKKDDNVI LHPGDIRLVS
LGFRGQLTVK QQINQRVEQH SHAFRSAADW MIQNQDKKGG WAVPVERSIA DRKLVLEPGW
HSAMAQGHGI SVLTRAYKYF NDTKYLLSAM QALELFKTNS SEGGVRAEFF GNVWYEEYPT
TPVSNLKMCR RYGWFDEIRT FLPTLWLILA PLILSPLLFF GQEGKCTFVI LTMSCYWVAE
VVPLAVTSFI PMIALPFLGI VSIKQVAPKY FADTNIVFFN SLMLSLAVEE CQLHKRIALK
LLTYVGTRPH WLMAGFMIIT SFISLWISDT ACCALMAPIA YALLEEIMIP KMKKAKNDEL
VEDKAFDDET EENMQMYDAT CGSCFFDWWN WNYKLNWTQS DFQR
//
