ID A0A261BT13_9PELO Unreviewed; 315 AA.
AC A0A261BT13;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=GDP-L-fucose synthase {ECO:0000256|ARBA:ARBA00012371};
DE EC=1.1.1.271 {ECO:0000256|ARBA:ARBA00012371};
DE AltName: Full=GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase {ECO:0000256|ARBA:ARBA00032995};
DE Flags: Fragment;
GN ORFNames=FL83_12497 {ECO:0000313|EMBL:OZG12875.1};
OS Caenorhabditis latens.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1503980 {ECO:0000313|EMBL:OZG12875.1, ECO:0000313|Proteomes:UP000216463};
RN [1] {ECO:0000313|EMBL:OZG12875.1, ECO:0000313|Proteomes:UP000216463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX534 {ECO:0000313|EMBL:OZG12875.1,
RC ECO:0000313|Proteomes:UP000216463};
RA Fierst J.L.;
RT "Caenorhabditis latens genome sequence.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the two-step NADP-dependent conversion of GDP-4-
CC dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a
CC reductase reaction. {ECO:0000256|ARBA:ARBA00002870}.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004883}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Fucose synthase subfamily. {ECO:0000256|ARBA:ARBA00005959}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZG12875.1}.
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DR EMBL; NIPN01000087; OZG12875.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A261BT13; -.
DR STRING; 1503980.A0A261BT13; -.
DR UniPathway; UPA00128; UER00191.
DR Proteomes; UP000216463; Unassembled WGS sequence.
DR GO; GO:0050577; F:GDP-L-fucose synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05239; GDP_FS_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00956; GDP_fucose_synth; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR028614; GDP_fucose/colitose_synth.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43238; GDP-L-FUCOSE SYNTHASE; 1.
DR PANTHER; PTHR43238:SF1; GDP-L-FUCOSE SYNTHASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000216463}.
FT DOMAIN 4..239
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OZG12875.1"
SQ SEQUENCE 315 AA; 35566 MW; A33009978DC6F599 CRC64;
MKTILVTGGT GLVGSAIKQV VETSEKREDE QWVFIGSKDC DLENIEETRK LFDTVKPTHV
IHLAAMVGGL FHNLAHNLKF FRKNMAINDN VLALCHEFDV VKCVSCLSTC IFPDKTTYPI
DEKMVHLGPP HDSNFGYSYA KRMIDVLNKG YAQEHGRKYT SVIPCNVFGP HDNYNLQSGH
VLPALIHKAY VAKRDDTSLE VFGSGKPLRQ FIYSLDLARL FIRVVREYED VEPIILSVGE
SDEVSIRDAV SAVVKAIDFT GNVEYDTSKA DGQFKKTASN EKLLKLFPDF KFTPFDQAIQ
ESVQWFVENY DSARK
//
