ID   A0A261CRR9_9PELO        Unreviewed;       799 AA.
AC   A0A261CRR9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Degenerin deg-1 {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=FL83_00109 {ECO:0000313|EMBL:OZG24626.1};
OS   Caenorhabditis latens.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1503980 {ECO:0000313|EMBL:OZG24626.1, ECO:0000313|Proteomes:UP000216463};
RN   [1] {ECO:0000313|EMBL:OZG24626.1, ECO:0000313|Proteomes:UP000216463}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PX534 {ECO:0000313|EMBL:OZG24626.1,
RC   ECO:0000313|Proteomes:UP000216463};
RA   Fierst J.L.;
RT   "Caenorhabditis latens genome sequence.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZG24626.1}.
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DR   EMBL; NIPN01000001; OZG24626.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A261CRR9; -.
DR   STRING; 1503980.A0A261CRR9; -.
DR   Proteomes; UP000216463; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF276; DEGENERIN DEG-1; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000216463};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        94..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        734..760
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          170..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:OZG24626.1"
SQ   SEQUENCE   799 AA;  90562 MW;  63849E3F13E18E84 CRC64;
     MLFCLNIAQR LVKDLAMSNH HSKTKKSSML PGREDYIYSH EIPNKEKSEK LNGASKHNDH
     INEDDETMKA KMMDFCDKTT AHGAKRVLIA RNSFSKLMWG MIIFSFLLMF AYQASKLILK
     FNAHEKITDI SLKFDDVEFP AITFCNLNPY KKSLVMMVPS IRDTMDVYDN AKSHSKTEGE
     KKKPKISRKQ HSDASQQMVR QLFAKEIEEG MVELKKSNMT LQMNNQAARN ISARRRSQRS
     VENRRYEAIE AHCKCVGNIG MECIRFESPP RDPSSKCICT YDRDMEVAWP CFNISVWYDH
     ECPLCHDDGY CESSLPYETT SSDKLPCMCR NRGDTSERED TPYCIGKAGE VGVGKTEIRK
     LWLENNMTTT TTTTTTTTPP PTTTSTTTTT TTTPEPTMRP NQSARVSNPE TIKAMGFQGM
     TDGVAMLTRA KENLMFTMAA LSDKQRIALS QSKHEFIEMC SFNGKECDID EDFRLHVDPE
     FGNCFTFNYD VNNNYTSSRA GPMYGIRVLL FVNTSDYMST SESSGVRLAI HPPTEYPFPD
     TFGYSAPVGF ASSFGIKKKV MQRLPAPYGE CIESKKVTDK NYIYTGYDYH PEGCHRSCFQ
     KGLIDDCSCG DPRFPVPEGS KHCSAFNATA RSCLEKNIGS VGDFHHITEK MDKCVCKQSC
     EEIIHEVTFS CSKWPSGATD LGDCEGMTEN ECEQYYRLNA AMIEVFYEQL NYELLQESEA
     YGLVNLIADF GGHLGLWLGF SVITVMEVCV LLVDMVSLFF KSRHEEKLRR ESTRRQNIPE
     DKRQITIGSG QKSDALVSI
//