ID A0A261F3C5_9BIFI Unreviewed; 1697 AA.
AC A0A261F3C5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=2-hydroxyglutaryl-CoA dehydratase {ECO:0000313|EMBL:OZG53426.1};
GN ORFNames=PSSU_0192 {ECO:0000313|EMBL:OZG53426.1};
OS Pseudoscardovia suis.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Pseudoscardovia.
OX NCBI_TaxID=987063 {ECO:0000313|EMBL:OZG53426.1, ECO:0000313|Proteomes:UP000216454};
RN [1] {ECO:0000313|EMBL:OZG53426.1, ECO:0000313|Proteomes:UP000216454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24744 {ECO:0000313|EMBL:OZG53426.1,
RC ECO:0000313|Proteomes:UP000216454};
RX PubMed=28764658; DOI=10.1186/s12864-017-3955-4;
RA Lugli G.A., Milani C., Turroni F., Duranti S., Mancabelli L.,
RA Mangifesta M., Ferrario C., Modesto M., Mattarelli P., Jiri K.,
RA van Sinderen D., Ventura M.;
RT "Comparative genomic and phylogenomic analyses of the Bifidobacteriaceae
RT family.";
RL BMC Genomics 18:568-568(2017).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZG53426.1}.
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DR EMBL; MWWQ01000004; OZG53426.1; -; Genomic_DNA.
DR Proteomes; UP000216454; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 4.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018709; CoA_activase_DUF2229.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 2.
DR Pfam; PF09989; DUF2229; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Reference proteome {ECO:0000313|Proteomes:UP000216454}.
FT DOMAIN 23..291
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 405..659
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 755..973
FT /note="DUF2229"
FT /evidence="ECO:0000259|Pfam:PF09989"
FT REGION 308..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1697 AA; 185169 MW; A078D78E27553156 CRC64;
MTDSFATNEM ETKEGTAHPR IRIGFDVGST TVKAVVLDMD APKPQAPAEP LTADDARVLF
SDYRRHHANV RATAEGLLTD IKKVLEDRGF ANVPVRLTIT GSGGLGLADG LGVPFVQEVI
AETDAINDAY PQADVIIELG GEDAKITYLK PTPEQRMNGS CAGGTGAFID QMATLLGTDA
QGLNDMAKQH TTLYPIASRC GVFAKSDLQP LINDGAAKPD LAASIFQAVS TQTIAGLACG
RPVKGTVVFL GGPLFFMSEL REAFHRTLED KVDTYITPEN AHLYVAYGAA IVSDDELELD
AHDEALPDES RGVEHDGTGE PAASDASATS ASAQEGSGDA PDRMIASTIE QLLARLDTLK
SQPSANKTMR PLFKDDAERR EFNDRHHREL IAQRTMEDAH GPLFLGIDAG STTIKATLVN
DDRDIVWSSY GTNQGSPLLA AAQIVKKIEA QLPDDAYIAR SCATGYGEGL ITAGLHVDEG
VVETMAHYRG AELVSPGVTS VIDIGGQDMK YLAINDGVIE SISVNEACSS GCGSFLQTFA
TSMDLTIEDF TKAALASTHP VDLGSRCTVF MNSSVKQAQK EGASIEDIAA GLCYSVVRNA
LYKVIKLRDA GDLGSTIVVQ GGTFLNDAVL RAFELLTDRK VTRPNIAGLM GAYGAALTAR
MHYEDGNTSA LLHGDALDHL SMTTSRDQCK LCQNHCKLTI TTFQDGSRYV TGNRCERGGD
RTKKKSPLPN LYDYKYRRAF AYRRLTEKAA TRGEIGIPRV LNMYENYPFW FTLLTTLGFR
VGLSGRSNHE LFEEGIDSIA SENICYPAKL AHGHIQDLLD KGYTTIFYPC VHFEDLDVQG
MDNRFNCPIV ANYPGVIGAN MAQLHQPGIR YMHPYFNLAN HKLIVDRIVE EFAWANVTRE
EAQQAVDAAY KEDKIFKHDV QQEGLRALAY MKEHNLRGIV LAGRPYHVDP EINHGIPEAI
TSLGMVVLSE DAVSWLEPGR KLNLTPFIGK DEVRPGSKDA DGFRKVDDEF NPYVSGAMSP
VRRVVDATGK SHASSQEVYF DGRGDVEEPL RVRNQWAYHA RLYAAARFVS EYPGLELVQL
NSFGCGLDAI TTDQVQEVLA EKDDVYTVLK IDEVSNLGAA KIRLRSLKAA IEEREAESRR
EAAAAGSAQA SAQSPAQGAT QASAQASQDA AQTSARNASV FRRTGTVRIG DRIVSRAQAD
QAAREAAQAA PNAVSRAAIE ANMGIESDSS NSRMSSRLSK YAHKVAFTKQ MKKDYTIVGP
QMSPFHFELL EAVFRSGGYK TDILRHASHA DIECGLKYVN NDACYPSIIV IGQLVNAIVQ
GKYDPDHTAL VITQTGGMCR ATNYFGLIRK ALVDAGYPQV PVIALSTQGI ESNPGFQITL
PLVHRAAKAL ILGDVLLKCV NRVRPYEQTR GSANELHRKW NIVIRETIEH HGHTEHGKEW
FGHGTYHYDR LVHDIVRSFD TLPLRDIPRK PRVGVVGEIL VKYHPDANNH VVDVIESQGC
EAVVPGMMEF MTQNFYTTDW NKHTLGTGGN RFGKGVLRWC VEKYEKPMND AFAASERFEP
DMPLPELIKR AQQVTSLGVQ AGEGWLLTGE IIELIESGAP NIVCAQPFAC LPNHVTGRGM
FHEIRRQHPN ANIVSIDYDP GSSEANQLNR IKLMIAAAKK MHAAGLDTRE ASARAAEAVE
DGKSAGEALR EAVRPVA
//
