ID   A0A261FD95_9BIFI        Unreviewed;       839 AA.
AC   A0A261FD95;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755};
DE            EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755};
GN   ORFNames=AEAE_0155 {ECO:0000313|EMBL:OZG56846.1};
OS   Aeriscardovia aeriphila.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Aeriscardovia.
OX   NCBI_TaxID=218139 {ECO:0000313|EMBL:OZG56846.1, ECO:0000313|Proteomes:UP000228976};
RN   [1] {ECO:0000313|EMBL:OZG56846.1, ECO:0000313|Proteomes:UP000228976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21773 {ECO:0000313|EMBL:OZG56846.1,
RC   ECO:0000313|Proteomes:UP000228976};
RX   PubMed=28764658; DOI=10.1186/s12864-017-3955-4;
RA   Lugli G.A., Milani C., Turroni F., Duranti S., Mancabelli L.,
RA   Mangifesta M., Ferrario C., Modesto M., Mattarelli P., Jiri K.,
RA   van Sinderen D., Ventura M.;
RT   "Comparative genomic and phylogenomic analyses of the Bifidobacteriaceae
RT   family.";
RL   BMC Genomics 18:568-568(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC         residues in alpha-D-galactosides, including galactose
CC         oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC         Evidence={ECO:0000256|ARBA:ARBA00001255};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZG56846.1}.
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DR   EMBL; MWWU01000001; OZG56846.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A261FD95; -.
DR   OrthoDB; 9758822at2; -.
DR   Proteomes; UP000228976; Unassembled WGS sequence.
DR   GO; GO:0004557; F:alpha-galactosidase activity; IEA:InterPro.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   CDD; cd14791; GH36; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR038417; Alpga-gal_N_sf.
DR   InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR   InterPro; IPR002252; Glyco_hydro_36.
DR   InterPro; IPR031704; Glyco_hydro_36_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE C-RELATED; 1.
DR   PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR   Pfam; PF16875; Glyco_hydro_36N; 1.
DR   Pfam; PF02065; Melibiase; 1.
DR   PRINTS; PR00743; GLHYDRLASE36.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000228976}.
FT   DOMAIN          49..297
FT                   /note="Glycosyl hydrolase family 36 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16875"
FT   REGION          754..803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        770..803
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   839 AA;  91062 MW;  0FAE4542BD38227D CRC64;
     MTELTSSAGV RIVSLNDTTL DGQHSLQGVY LESDNGEVGV ALVARDKELP RLVHWGRALA
     HPRHVLHLYE AQRPQRVSGE LDDTTWPSIL PTQAEAWIGA KRLDIRRGTR ELFLNFELQE
     ITTTLIDPAQ GDGLDAELDP GAAGGVQVNV IARDSAQNIA VNWRLQMLPG GLIRQSARLV
     NNEPMASGEN NGADNLEISK VELGWPLPSR ASEVLTTTGH HLHERRAQRQ KLSMSRIEKV
     AMAGRPDFDF SLLLAAGTPG FSFEEGEVYV EHLGWSGNSV MAAEKLPYCE PQISGAELLY
     GGEVSLEPGD TYATPWLYGS YGNGLNEASK RYHRFVRAAH PCFAQVQRPV LLNTWEAVYF
     EHSYATLAAL ADKAADAGVE RFVVDDGWFM HRRSDNAGLG DWSVDPAVWP EGEHSLKALA
     DHVHAKGMQF GLWFEPEMIN PDSDTARAHP EWILRASASN QPGSELGRLP MQGRNQQVID
     LTNPAAYEHV FNAMDTLVSQ LHIDYIKWDH NKLVTEPISP YSGRPAVHEQ TRAVYSIFQG
     LKKNHPGLEI ESCSSGGGRI DLGMLRFADR VWVSDCVDPV EREENQRWDS VIVPPEILGE
     HIGKSPADST KRATSLSLRA AMAFFGHLGV EWNLLTVPAE QLEQLAVWVD AYKALRPLFS
     TGMVVHSGPD DSDEPAAYVD GVVAQDGSKA VYRFTQLTAS RSYPAEPVRL PGLNPRSLYR
     VSLLPASVAD MPEKGNGQSD LLWAVGGGAR GGAAGARGGA AGAGASSKSA VSEGEVSEVS
     SKSAVSEGEV SEVSSASPVS PAFSGSVTLD GEALSRYGIR PPSLHPAQAV LFVVDEVEE
//