ID A0A261GCN4_9BIFI Unreviewed; 401 AA.
AC A0A261GCN4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:QOL31300.1};
GN ORFNames=BE0216_01605 {ECO:0000313|EMBL:QOL31300.1}, BEUL_0594
GN {ECO:0000313|EMBL:OZG69188.1};
OS Bifidobacterium eulemuris.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1765219 {ECO:0000313|EMBL:OZG69188.1, ECO:0000313|Proteomes:UP000216057};
RN [1] {ECO:0000313|EMBL:OZG69188.1, ECO:0000313|Proteomes:UP000216057}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100216 {ECO:0000313|EMBL:OZG69188.1,
RC ECO:0000313|Proteomes:UP000216057};
RX PubMed=28764658; DOI=10.1186/s12864-017-3955-4;
RA Lugli G.A., Milani C., Turroni F., Duranti S., Mancabelli L.,
RA Mangifesta M., Ferrario C., Modesto M., Mattarelli P., Jiri K.,
RA van Sinderen D., Ventura M.;
RT "Comparative genomic and phylogenomic analyses of the Bifidobacteriaceae
RT family.";
RL BMC Genomics 18:568-568(2017).
RN [2] {ECO:0000313|EMBL:QOL31300.1, ECO:0000313|Proteomes:UP000593943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100216 {ECO:0000313|EMBL:QOL31300.1,
RC ECO:0000313|Proteomes:UP000593943};
RA Kim J.;
RT "Genome sequencing of Bifidobacterium eulemuris_DSMZ_100216.";
RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; MWWZ01000004; OZG69188.1; -; Genomic_DNA.
DR EMBL; CP062938; QOL31300.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A261GCN4; -.
DR KEGG; beu:BE0216_01605; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000216057; Unassembled WGS sequence.
DR Proteomes; UP000593943; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 2.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 104..304
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
FT REGION 299..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 42844 MW; 2248D26354A02C90 CRC64;
MTQSRRMLVL RAVVEDYIRS QEPVGSSALT KQHDLGVSSA TIRNDMAALE DEGYLIQPHT
SAGRVPTEKG YRYFVDRLAT VVPLSAAQRR GIDSFLSGSV SLQDTLRRAA RLLSEITGQV
AVVAAPSLAK STLRHVELVP VAMNTLLAVV ITDTGRVAQH TIVVNPMPEQ DAAARFTNAV
NAEAASLPLM AAARKARSMA AMAQWKELSP LAESLAQAFE NMADSERTNE LYMSGTSRLA
QQHAAIDDLA PLFDALEEQV MLMRLMSAMP RHDGVGVAIG SETHTPGLLH ASVVASGYGQ
TKTRTGGGED HDAADGSSPD RRNSDMNPSR TSKQSGDMID RHTAYDEHAV QTDDIGQNDA
EPVAFVGSIG PTHMDYAATI AAVQAVARYL TASLAHGDDG D
//
