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Database: UniProt
Entry: A0A261UNP4_9BORD
LinkDB: A0A261UNP4_9BORD
Original site: A0A261UNP4_9BORD 
ID   A0A261UNP4_9BORD        Unreviewed;       822 AA.
AC   A0A261UNP4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OZI62992.1};
GN   ORFNames=CAL28_28165 {ECO:0000313|EMBL:OZI62992.1};
OS   Bordetella genomosp. 11.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=1416808 {ECO:0000313|EMBL:OZI62992.1, ECO:0000313|Proteomes:UP000215767};
RN   [1] {ECO:0000313|EMBL:OZI62992.1, ECO:0000313|Proteomes:UP000215767}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AU8856 {ECO:0000313|EMBL:OZI62992.1,
RC   ECO:0000313|Proteomes:UP000215767};
RA   Spilker T., LiPuma J.;
RT   "Complete and WGS of Bordetella genogroups.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZI62992.1}.
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DR   EMBL; NEVS01000004; OZI62992.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A261UNP4; -.
DR   OrthoDB; 5287258at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000215767; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}.
FT   DOMAIN          31..213
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          216..315
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  88426 MW;  F975DD5027DD3C30 CRC64;
     MNTAAETQPG PHAPAAGHAA PPRSAPRIRR VAILGAGVMG AQIAAHCVNA RIPAVLFDLP
     ADGPDRSATA RKAIEGLARL NPAPLAAAEL AAHIRPANYD ENLDLLAGCD LVLEAIAERL
     DWKQDLYRRI VPALAPHAIL ATNTSGLSID ALAATLPEAM RDRFCGVHFF NPPRYMPLVE
     LIPASRTDAA LLDRLETFLT TDMGKRVVRA KDTPNFIGNR IGVFGILAAM IEAERHGLAY
     DVVDELTGSR LGRAKSGTFR TADVVGLDTL AHVIHTMQTG LPDDPFHAAF ATPPVLAALL
     EQGALGQKTG AGFYRKEGKT ILRLDPATRQ YVASDARLEE ATVAALAERD PALRLRALHD
     STEPQGRFLW ALLRDTFHYS AVHLAEIAHT ARDVDFALRW GFGHAKGPFD IWQAAGWTTV
     AEWIQEDIAQ GRALSPVPLP DWAMRGPVPE HGGVHTAGGS WNAEVKAFQP RRELPVYRRQ
     LAPPRLVGET HEAPGRTVYE DAAICLWTLA RDGHDDILIA SFKTKMHTIS PAVTQGLLRA
     VDLAEERYRG LVVWQTGQPF SAGADLQAML PAFMQGGPAA IEPMERDLQR VAQRFRSALV
     PTVVALSGLA LGGGCEIAVH ASARVAHLET HIGLVEVGVG LVPGAGGLAY CARRAAEQRA
     ACAPDAPLLP FLQKFAEAVA TAKVSRSALE ARQIGYLRET DPIVMNEDEL LHVAIGHAAA
     LADAGWRPAL DAPFPVAGRD GAATLSAQLV NMRDGGFISE YDYELGRTVA HVICGGDVDP
     GTLVDEEWML ALERRAFLGL LENPKTHERI MGMLKTGKPV RN
//
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