ID A0A261UNP4_9BORD Unreviewed; 822 AA.
AC A0A261UNP4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OZI62992.1};
GN ORFNames=CAL28_28165 {ECO:0000313|EMBL:OZI62992.1};
OS Bordetella genomosp. 11.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=1416808 {ECO:0000313|EMBL:OZI62992.1, ECO:0000313|Proteomes:UP000215767};
RN [1] {ECO:0000313|EMBL:OZI62992.1, ECO:0000313|Proteomes:UP000215767}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU8856 {ECO:0000313|EMBL:OZI62992.1,
RC ECO:0000313|Proteomes:UP000215767};
RA Spilker T., LiPuma J.;
RT "Complete and WGS of Bordetella genogroups.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZI62992.1}.
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DR EMBL; NEVS01000004; OZI62992.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A261UNP4; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000215767; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 31..213
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 216..315
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 88426 MW; F975DD5027DD3C30 CRC64;
MNTAAETQPG PHAPAAGHAA PPRSAPRIRR VAILGAGVMG AQIAAHCVNA RIPAVLFDLP
ADGPDRSATA RKAIEGLARL NPAPLAAAEL AAHIRPANYD ENLDLLAGCD LVLEAIAERL
DWKQDLYRRI VPALAPHAIL ATNTSGLSID ALAATLPEAM RDRFCGVHFF NPPRYMPLVE
LIPASRTDAA LLDRLETFLT TDMGKRVVRA KDTPNFIGNR IGVFGILAAM IEAERHGLAY
DVVDELTGSR LGRAKSGTFR TADVVGLDTL AHVIHTMQTG LPDDPFHAAF ATPPVLAALL
EQGALGQKTG AGFYRKEGKT ILRLDPATRQ YVASDARLEE ATVAALAERD PALRLRALHD
STEPQGRFLW ALLRDTFHYS AVHLAEIAHT ARDVDFALRW GFGHAKGPFD IWQAAGWTTV
AEWIQEDIAQ GRALSPVPLP DWAMRGPVPE HGGVHTAGGS WNAEVKAFQP RRELPVYRRQ
LAPPRLVGET HEAPGRTVYE DAAICLWTLA RDGHDDILIA SFKTKMHTIS PAVTQGLLRA
VDLAEERYRG LVVWQTGQPF SAGADLQAML PAFMQGGPAA IEPMERDLQR VAQRFRSALV
PTVVALSGLA LGGGCEIAVH ASARVAHLET HIGLVEVGVG LVPGAGGLAY CARRAAEQRA
ACAPDAPLLP FLQKFAEAVA TAKVSRSALE ARQIGYLRET DPIVMNEDEL LHVAIGHAAA
LADAGWRPAL DAPFPVAGRD GAATLSAQLV NMRDGGFISE YDYELGRTVA HVICGGDVDP
GTLVDEEWML ALERRAFLGL LENPKTHERI MGMLKTGKPV RN
//