ID A0A263CVC1_9PSEU Unreviewed; 1557 AA.
AC A0A263CVC1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OZM69919.1};
GN ORFNames=CFN78_28050 {ECO:0000313|EMBL:OZM69919.1};
OS Amycolatopsis antarctica.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1854586 {ECO:0000313|EMBL:OZM69919.1, ECO:0000313|Proteomes:UP000242444};
RN [1] {ECO:0000313|EMBL:OZM69919.1, ECO:0000313|Proteomes:UP000242444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU-G6 {ECO:0000313|EMBL:OZM69919.1,
RC ECO:0000313|Proteomes:UP000242444};
RA Wang J., Leiva S., Huang J., Huang Y.;
RT "Amycolatopsis antarcticus sp. nov., isolated from the surface of an
RT Antarcticus brown macroalga.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZM69919.1}.
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DR EMBL; NKYE01000031; OZM69919.1; -; Genomic_DNA.
DR InParanoid; A0A263CVC1; -.
DR Proteomes; UP000242444; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242444};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..97
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 113..534
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1444..1519
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1557 AA; 163106 MW; A0341C50EF7F282B CRC64;
MPFVRSRSGD DENEVGRVRA GPRECLEGVR DAVATVLGVE PDSVAVHVPL RELGIDSVGL
TRLTAAIGER LDAEVPSWAV WQCPTVATLA EFLSDGSPRA PAGRASRSAN PATEPVAIVG
MGCRLPGGID SPERLWAALR SEVDAVGTVP ADRWNAGEWY DPDQSAPGKT TTDRGGFLDD
ITGFDAAFFR VSPAEAERMD PQQRIALEVV WAALEDARIV PAALSGTRTG VFFGTMWQEY
HLATGADPAG IGPHSAVGWD TSIVPSRIAY VLGLQGPVLS VGSACSSSLG AVHLAAHSLR
RGESDIALAG GVSLMLHPHT TVAMTKFGGL NPDGQCRAFD ADAAGYVRSE GCGVVVLRRL
SDALRDGDRI YAVLRGSAVN NDGASNGLTA PNPRAQVDVL RTAWAEAGVR TDQVSYVEAH
GTGTPLGDLI EASALGEVFG PGRTEPLRIG SAKTNFGHLE PAAGVLGVLK TALALHHGEL
PASLHFDRPN PEIDFVGQKL AVVTERQSWP VGPRYAGVSA FGFGGTNVHV ALEQAPHRRR
RLLAVAADTE PALRARLAAV STAGDIPMSP GPGHHRAVAW LDGCGDPAAT ARVAQVGDRP
KVVFCFSGHG AQWLGMGAGL LAEPVFRAAI EDVDRALAPV TGWSVLDELL APRLDRADVV
QPALFAVQVA LTRLLAAWGV SPDVVFGQSV GEVAAAVATG ALFLDQGAEL IGRWSRLVAE
RASGSGSMIV CDLPAAAADR ISRGRLSIAA AVAEDWTCLS GSTGALVEVE RDLAQAGATV
RRVAIDYPAH STELAAITPD LVAELAGLRA GQGTIPFLST VTGGPLPGTR LDAGYWARNT
CQPMRLTEVA AALPADAQVV EIGPHPVLAQ PMRRLLAPGS RVLAACHRDV PARQTVEDLL
AELWLSGVEV DWAAATGVPA PTVEPVPLTV SSATRTGLRA QAAAMREHLA AHPEQSLAEV
GHSLVATRSM FDHRAVVLAA DRDQATSGLD ALAAGVPHPG LVTAATEPVR DTAGPVLVFP
GQGSQWTGMA RELLADSPVF AARFAECAAA LDEFVEWSLI DVLADEAALA RADVVQPALW
AVMVSLARLW EAHGLRPTAV VGHSQGEIAA ACVGGALSLR DAARVVASRA RVIADTLSGS
GGMVSVALPR DEAAERAGGW DRRLSVAAEL GPRSTVLAGP DDALEGLMTR CAEAAVVARR
VAIDYPSHSP GVDPARAEVL AALTGVEPQP AELTHVSTVT GKPLAGVELD ADYWYRNLRE
PVELRAVVDL LLDRGHRVFV EASPHPVLSP GIEETAAARG LDVVAVASVR RGDGGLSRFL
TSVTEAHVRG VDLDWALVLS SAGPVDLPTY QFQRRDYWPR VDRRSGAADP ADAEFWGAVE
RGDLGALRDT LNLPADATLA DLLPALARWR RERIQPEVPE PAPEPAPAAL VELLAGQPPA
RRLELVTDVV LRNAAAVLGY RGDEPAAPER AFRELGFDSV SGLDLRNRLA AELGLALPPT
LVYDQPTPAA LAGHLLAELD LDSSAPDPDT AVSASIADAA DDELFDLIDS LTSRRTS
//
