ID   A0A263HAT9_9PAST        Unreviewed;       562 AA.
AC   A0A263HAT9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=protein-N(pi)-phosphohistidine--D-fructose phosphotransferase {ECO:0000256|ARBA:ARBA00012799};
DE            EC=2.7.1.202 {ECO:0000256|ARBA:ARBA00012799};
GN   Name=fruA {ECO:0000313|EMBL:SUU38664.1};
GN   ORFNames=NCTC10851_02203 {ECO:0000313|EMBL:SUU38664.1};
OS   Actinobacillus seminis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=722 {ECO:0000313|EMBL:SUU38664.1, ECO:0000313|Proteomes:UP000254507};
RN   [1] {ECO:0000313|EMBL:SUU38664.1, ECO:0000313|Proteomes:UP000254507}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10851 {ECO:0000313|EMBL:SUU38664.1,
RC   ECO:0000313|Proteomes:UP000254507};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC         fructose 1-phosphate(in) + L-histidyl-[protein];
CC         Xref=Rhea:RHEA:49252, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746,
CC         ChEBI:CHEBI:29979, ChEBI:CHEBI:37721, ChEBI:CHEBI:58674,
CC         ChEBI:CHEBI:64837; EC=2.7.1.202;
CC         Evidence={ECO:0000256|ARBA:ARBA00001401};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UFSB01000001; SUU38664.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A263HAT9; -.
DR   InParanoid; A0A263HAT9; -.
DR   OrthoDB; 9782569at2; -.
DR   Proteomes; UP000254507; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   CDD; cd05569; PTS_IIB_fructose; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   InterPro; IPR036095; PTS_EIIB-like_sf.
DR   InterPro; IPR013011; PTS_EIIB_2.
DR   InterPro; IPR003501; PTS_EIIB_2/3.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR013014; PTS_EIIC_2.
DR   InterPro; IPR003353; PTS_IIB_fruc.
DR   InterPro; IPR006327; PTS_IIC_fruc.
DR   NCBIfam; TIGR00829; FRU; 1.
DR   NCBIfam; TIGR01427; PTS_IIC_fructo; 1.
DR   PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR   PANTHER; PTHR30505:SF0; FRUCTOSE-LIKE PTS SYSTEM EIIBC COMPONENT-RELATED; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   Pfam; PF02302; PTS_IIB; 1.
DR   SUPFAM; SSF52794; PTS system IIB component-like; 2.
DR   PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR   PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ   SEQUENCE   562 AA;  58397 MW;  911A44D9C88D9797 CRC64;
     MNIYLTQSSQ LGNAKIFLLH QAVSAAMKQQ GNQVVNQVER ADLAIVFGDS LPNNPHLVGK
     KVFLADAEQA FNAPENLLRQ ALNQAQDYVL PNPVESAVNS AAISPNSVKN IVAVTACPTG
     VAHTFMSAEA ITEYGKKQGW NVKVETRGQV GAGNPISPEE VAAADLVFVA ADIDVDLSKF
     VGKPMYRTST GLALKKTAQE FDKAFKEATI YSVSRAEKVK EENIGEKKGV YKHLMTGVSH
     MLPLVVAGGL LIAISFMFGI EAFKDANIAG GLPKALMDIG GGGAFHLMIA VFAGYVAFSI
     ADRPGLAVGL TGGMLATSAN AGILGGIIAG FLAGYVVKFL NNIIKLPASV NSLKAILILP
     LLGTAIVGLA MVYLINPPVA SIMTALSDWL SSMTGTNAIL LGIILGGMMC VDMGGPVNKA
     AYAFSVGMIA SNVTLPMAAA MAGGMVPPIG MAIATWIARR KFNVNQHNSG NTAFILGLCF
     ISEGALPFVA ADPIRVIVSS VIGGATAGAI STGLGITLNA PHGGLFVIPF VSQPLMYLLA
     ITVGSLVTGV IYGLIKPKLT EN
//