ID   A0A264W5G9_9BACL        Unreviewed;       740 AA.
AC   A0A264W5G9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:OZS78833.1};
GN   ORFNames=CF394_04660 {ECO:0000313|EMBL:OZS78833.1};
OS   Tetzosporium hominis.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Tetzosporium.
OX   NCBI_TaxID=2020506 {ECO:0000313|EMBL:OZS78833.1, ECO:0000313|Proteomes:UP000217065};
RN   [1] {ECO:0000313|EMBL:OZS78833.1, ECO:0000313|Proteomes:UP000217065}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VT-49 {ECO:0000313|EMBL:OZS78833.1,
RC   ECO:0000313|Proteomes:UP000217065};
RA   Tetz G., Tetz V.;
RT   "Tetzosporium hominis gen.nov. sp.nov.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZS78833.1}.
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DR   EMBL; NOKQ01000187; OZS78833.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A264W5G9; -.
DR   OrthoDB; 9770103at2; -.
DR   Proteomes; UP000217065; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000217065};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          68..310
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          356..701
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          712..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..730
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  83513 MW;  F038DD565758573C CRC64;
     MKKIKSQTTR TSKSKQRAHL IFRMNVLFLT IFLLFTALIF RLGYLQIVKG EDYTRILART
     EEVPVNTSVP RGRIFDSQGR ILVDNQAERA ITYTKMQTTT GDEMWGIAEK LAALIEKDTD
     SITKSDLQDY WLRKNKDDMY KYVDKAEQDA IEDSEELDNV EKSREMNRLI RDSIPEQELN
     AFSKDELEKI AIYREMVSGY ALSPQIIKGE NVSAEEFARV SERLNELQGV NTTTDWRRVR
     NSNLAILGTT TLPKEGIPKS DLNHYLARDY SRNDRVGRSY VEQYYEEVLQ GQKSVVKNIT
     DGKGRVIDTQ PVYEGDPGKD LVLSIDTEVQ ARLEEIVTAR LLEAKRNAGT RHLDRMFFTM
     MDPNTGEVIA MVGKILRRDP ETSEFARDPE TGGYIVDDYA FGTFTTAYEA GSTIKGGTVL
     TGYRENALSI GETKIDEPIY IANDDAKSSV FNRSGRIPVN DLTALERSSN VYMYKIAFTL
     AGETYRPKES VDFNFNAFDK LRNGYAQLGL GVPTGIDLPG EVAGFSNPEN DEAFNLLDLS
     IGQYDTYTPL QLTQYIATIA NGGKRIQPHV VKEIRKASEN GEEMGALEAE IQPKVLNIVE
     NTQAEIEQVR KGMRRVYQGD QGTARGAFAD FKYDGAGKTG TAETSAYDPV EKKLYDTVTL
     SHVGFAPYDN PQIAYSTMIP WASLESVYKT NSSTPLTREL VDAYFEIMEK RNSEQKEESL
     HPKIIPSISE DSIDEEEETE
//