ID A0A265Q9I9_9FIRM Unreviewed; 470 AA.
AC A0A265Q9I9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Na+/H+ antiporter NhaC {ECO:0000313|EMBL:OZV12505.1};
GN Name=nhaC {ECO:0000313|EMBL:OZV12505.1};
GN ORFNames=CIW83_09000 {ECO:0000313|EMBL:OZV12505.1};
OS Tissierella sp. P1.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Tissierellaceae;
OC Tissierella.
OX NCBI_TaxID=1280483 {ECO:0000313|EMBL:OZV12505.1, ECO:0000313|Proteomes:UP000216906};
RN [1] {ECO:0000313|EMBL:OZV12505.1, ECO:0000313|Proteomes:UP000216906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1 {ECO:0000313|EMBL:OZV12505.1,
RC ECO:0000313|Proteomes:UP000216906};
RA Bukhtiyarova P.A., Antsiferov D.V., Avakyan M.R., Frank Y.A., Ikkert O.P.,
RA Pimenov N.V., Brasseur G., Tuovinen O.H., Karnachuk O.V.;
RT "Isolation and Characterization of an Anaerobic Sulfidogenic Tissierella
RT from Cu-bearing Coins.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OZV12505.1}.
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DR EMBL; NPMN01000010; OZV12505.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A265Q9I9; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000216906; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000216906};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 9..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 160..453
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 470 AA; 49545 MW; E8CF6C3C339FBD31 CRC64;
MKKTARKPYL WEALLSFAFL IIVMGVSISI YEADPHIPML VGTLFAALIA VKIGFTWNEI
EKAMFDGIYQ ALQAIIILAI IGVLIGLWLL SGVVPSMIYY GLGILKPGIF LVATVLICSI
TSLATGTSWG TAGTIGIALI GIAKGLGIPA PVAAGAIISG AYLGDKMSPL SDTTNLAPAV
SGTDVFTHVK NMVPSTFTAY GITLVIFLIM GFKYGGGSVD ISAIDAIRDG ITSSFNVSPL
LLIPPLAVIV AIAFKVPAIP GITIGIILGG VLGVVMQGAH LGDLLTAAFS GYTSQTGVEM
IDELLTAGGL ENMMFSISLT IIAMMFGGIM EKTGQLEVIV GALLKRVKRV GTLVTTTILT
CVFSNVTMPE QYISVVVPGR MYAKAYREKG LHPKVLSNAL EGAGTITSAL IPWNTCGAFL
YSVLGVATQD YAKYAFFNYI TPIVIIIFAY IGINLPKIED DPDTVIGLEN
//
