ID A0A267DDI5_9PLAT Unreviewed; 332 AA.
AC A0A267DDI5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN ORFNames=BOX15_Mlig009773g3 {ECO:0000313|EMBL:PAA46639.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA46639.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA46639.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA46639.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA46639.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA46639.1}.
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DR EMBL; NIVC01004764; PAA46639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DDI5; -.
DR STRING; 282301.A0A267DDI5; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR Gene3D; 6.10.250.1780; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR041448; TNFR16_TM.
DR PANTHER; PTHR46605:SF2; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46605; TUMOR NECROSIS FACTOR RECEPTOR; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF18422; TNFR_16_TM; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..275
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 37350 MW; 82DD7F044E056581 CRC64;
MAPTTSPDAT ELSPGAVTAD SVFRDLQQQQ QQPAEEGSFL RKQQKQPQSR PLSDWKELID
NGNPRPPINL ARFNLTQVAR TEEPVSRHSG SRNDMIPVYC AVLGAIIVSL IVWIVFKYFR
SRTYSRKTQQ HLPASNALIP PQSPMYPPPR SCQPAALLKR RSVDSGFGGS EALAASVSSS
TRPLKEISDS RFQRLENILS NNPDPAAWKE LATELGFSAD EVQEFEAQAD ALRQSPIRLM
LRTWSQRPGA TIGLFGRCLQ KAGRKDALIL FKELAERQHQ QQHQQQHGAG RRQSAQPRQT
GQQQQQQQQQ QQQQQQQQQL AEEPSLQEMC QV
//
