ID A0A267DFL5_9PLAT Unreviewed; 605 AA.
AC A0A267DFL5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Quinolinate phosphoribosyltransferase [decarboxylating] {ECO:0000256|ARBA:ARBA00033102};
GN ORFNames=BOX15_Mlig016991g2 {ECO:0000313|EMBL:PAA47946.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA47946.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA47946.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA47946.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA47946.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the catabolism of quinolinic acid (QA).
CC {ECO:0000256|ARBA:ARBA00003237}.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004790}.
CC -!- SIMILARITY: Belongs to the NadC/ModD family.
CC {ECO:0000256|ARBA:ARBA00009400}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA47946.1}.
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DR EMBL; NIVC01004281; PAA47946.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DFL5; -.
DR STRING; 282301.A0A267DFL5; -.
DR UniPathway; UPA00253; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1170.20; Quinolinate phosphoribosyl transferase, N-terminal domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR027277; NadC/ModD.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR InterPro; IPR037128; Quinolinate_PRibosylTase_N_sf.
DR InterPro; IPR002638; Quinolinate_PRibosylTrfase_C.
DR InterPro; IPR022412; Quinolinate_PRibosylTrfase_N.
DR PANTHER; PTHR32179; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]; 1.
DR PANTHER; PTHR32179:SF3; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]; 1.
DR Pfam; PF01729; QRPTase_C; 1.
DR Pfam; PF02749; QRPTase_N; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
DR SUPFAM; SSF54675; Nicotinate/Quinolinate PRTase N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 66..138
FT /note="Quinolinate phosphoribosyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02749"
FT DOMAIN 141..304
FT /note="Quinolinate phosphoribosyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01729"
FT REGION 353..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 61337 MW; B1F87EBD5DD647BD CRC64;
MTHITSLSAI KNIVKLWIEE DNIISNSGGV FVQFDSNASR LNFHNTGENG QTCEDDTEVN
SFNEHPVLCA VIFETKGVLA GVPFADALLT RLRCEASWSV AEGAYISSVP QRVATISGSP
VCLARARRLL PAVLSRASGL ATYANRLVEK AALCDWPGSV CADSDSRCTP GQRLLERHGL
LVGGVRPSAS STASTGGAVV IVDTTAAGGG GGSGVASALA GARRCAAPFG RVAAVCADEA
EALRACRLGA DLVMLECSSA EVCTAAARAV KAAHPGTLVQ ARQLAASDLA AYFTADIDVV
CVDASPAQLR SDWPEVALRP IAAGTAAFSD AAATAAVAAA AVAAAAAMPA RKRRRCASQD
SNPPRPPTAP VLGSTAAATA AAAAAAVAKQ PRLDLATSAT GSAGVGGGSS NPTTPTPQMV
NSCRELVPVF NTDRRNSQQS EQSEQPQQRR QRRESPPQPP LSAAASAAAS AAVSAAVAAS
AARAAAAVAG GAARPAAVLS VPYGFLRVPV SGVAGTPIRM VAPQSRAAAA AAAAAAAAAA
AYRNAQHRQP MTPAAAMAMR FGSVGYGTSV SAAQLLMGPW LCKVCRGANM YTTVCRHCSR
NRGLY
//
