ID A0A267DHE8_9PLAT Unreviewed; 918 AA.
AC A0A267DHE8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=BTB domain-containing protein {ECO:0000259|SMART:SM00225};
GN ORFNames=BOX15_Mlig004640g1 {ECO:0000313|EMBL:PAA48064.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA48064.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA48064.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA48064.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA48064.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA48064.1}.
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DR EMBL; NIVC01004246; PAA48064.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DHE8; -.
DR STRING; 282301.A0A267DHE8; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF286; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 199..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..149
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..31
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..716
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 101076 MW; 86A983AA23BE3558 CRC64;
MITKPREPLR IRTSPLQQPH HHHHHHHHHQ PHSGEADRPR RVVLNVGGER HEVMWRTLDR
LPKTRLGRLR LAGSPEEIRE LCDDYSACEG EFYFDRHPKF FHPVLNFYRT GKLHMSDDVC
VISFAAELKY WGISEDYFDL CCQHKYHQKK ETAEEEIRKD MEAVKWNQRN VEHDFGFGRY
GEFKRIVWNI LEEPQTSTLA RVVAIISILF IVLSTVGLTL NTIPELQLNQ TKVVGTNSSA
QVVWSLEDNP RLEIVEAVCI VWFTLEYVLR LWASPDTCKF LKGPMNVIDL IAIVPYYLSL
ILMRSLQDDS GGESYNSLTS VRKIVQIFRI LRILRVLKLA RHSTGLQSLG YTLRRSYKEL
GLLIMFVLLG VLLFSSLAYF AEKDEPGEGD RPNPFKSIPA TFWWAAITMT TVGYGDIVPK
TFLGKLVGSV CCICGVLVVA LPIPIIVNNF AEYYKEQSRR EKAQRRMEAI DAAKRKGSLI
SVASVAGIRR RASHESGSAG GGASTATGPA IGPDRVSGGS SGGCSDRHQQ HLLQHQHHQH
HQHHQHHQHE LEPLVCFQNP VAGRGVAEDP AGEIGTTGSL ELADGGRELR TSWLRSGRLG
PANQQQATAA SLGAAEILYI DSEDENCRGA SRFQQHQQPQ SQQQQQLLPS RESSLTRSLS
SAAAAAAAAA AGRTAGLASH SHSLASSDSF LTCNSHAPSS PVEPPQPQPP PGPPASSSHR
DRSDSSATAT TCSTAVAPGR SNNQSPSLSL SPASCPACQQ SPVPPQRLPP RREKIHFAAE
DEELQTPPPQ STSPMSPLQP PLPPAGQPKK KPTLRERFKN SAKKELQMTA DSPESKRLLS
RSAAATSPTS ATPSPEFPRA PAAQQPPQQQ PPQQHSILKN KDSTPPARME AIVEDLSSLT
GLHQLDSGLS EAASEAAP
//
