ID A0A267DJA0_9PLAT Unreviewed; 934 AA.
AC A0A267DJA0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=PBPe domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig002395g2 {ECO:0000313|EMBL:PAA60517.1},
GN BOX15_Mlig002395g3 {ECO:0000313|EMBL:PAA48797.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA48797.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA48797.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA48797.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA48797.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA48797.1}.
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DR EMBL; NIVC01004051; PAA48797.1; -; Genomic_DNA.
DR EMBL; NIVC01002143; PAA60517.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DJA0; -.
DR STRING; 282301.A0A267DJA0; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF411; IONOTROPIC RECEPTOR 25A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..934
FT /note="PBPe domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011915937"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 413..808
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 423..480
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 888..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 102612 MW; 1DCECE0709F4719F CRC64;
MSPKKQHFNF LLLLLLVMGQ QSFGMIGNTY YFLAVYDAQN RDLLAAAQKA IADLNAGTPS
AVLPAGKTIN VTAVQSGSES LFQTVCKTGN EHLLWIDGIL DFTARPSCVE DLARNLDAPI
IRASMELTND VPNVHPSPRN YMRAVAALLL RDNATRDGIM VLYDASFDAG SILPYEDYSW
YPPIYLRKIP TTAVEVATLL DEAKTLRIAD FVVASSVSNA AMVVQQAGVK SLMGGIYHWF
VVTKDLQDFS CSGCGSGSSL FFFRQTAADA TRATAVFTAV QSATGVAVAE SRKVDVLFAY
EAAETMGRVI KAQTDAGSFG NATNWLVCSG AYSPSTPVRY NDYTAKLKAL PSFSSVMGNV
AFANTLRNTD TTFKIAQIVY PGPTVNNIGT WTKAAGLAGS VSTISLSYMT IRNLIVRLTH
DPPFVIKKTD GTFEGYSIDM LKNLATNMNF NYTLVEQTDG IYGTLQSDGT WNGMMGALAS
GVADMAIGPI TVTAQREQIA DFTVPIYDYV SLQILLLQPT SSKGDQTFFL KAFTWDVWVS
IIAIITFTGF LIFFVDKVSP FSFQNRYRND QIREGEAEGK VFTVKESLWY VLGAYTQAGE
SFDPRSMSCR TIIVGFWLFG YLMMSLYTAN LAAQLTVDKL SQPPQSFDEL TTQVAMKYTV
IKDTASYEHF MRMKDAEANL YNYWLTSGIG TEETVDQLAS LVTWKYPVIE RYTTVWNRMT
KWGFATSTEQ ALDRVRKENI AIFLESSLVK YYTAKTCDFM TVGDPFAPRP YGIALRNKSP
LLKQMNVAIL SLNENRVTET LKQYWWSRDK VTCQATSSAS SGLSLDTLGG AFIFFCIGVG
IALIMFVAEK IVAKVYGVEW AKNNADAKQV NTLMMMMGPS TANLRASNSS IRPATGGLPR
PMTGHGRGSG TGHGRNSVEP VKSPDVMELE QGAR
//