ID A0A267DJR8_9PLAT Unreviewed; 596 AA.
AC A0A267DJR8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig016990g3 {ECO:0000313|EMBL:PAA48947.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA48947.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA48947.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA48947.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA48947.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA48947.1}.
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DR EMBL; NIVC01004010; PAA48947.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DJR8; -.
DR STRING; 282301.A0A267DJR8; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 596 AA; 67609 MW; D23540CF0F196849 CRC64;
MSKTLAFPKF LVSTFIENTT IRGIKKCYTT KYSALRLLWL LYLISMAVLL GYGTCDLFSE
FFEYHKSYQI EKRLNDPTPF PSLTICSMSP FSARALKLWR EGRIASPAEF SRQLRRGMGD
FLRDGRYKEA ASLFHSDKVS TYFQFINESS AKQLAYSFND LMPFCIMRHS ANGNPSVAHE
EDCEFQESSS FHHPDFFFCH DLELLQPDSS YVSSLSILLS NAHQNEMLMN DFNLTESDLE
DSSSEDYAFN VFNEASGFRI VLHEPGTYPL IDTQSFSVQM QTSTLIKYRP VKVEKQNYPE
GECSEASQLP IIQDDDSKYL YTFDACLSSH IGQLITEKCN CTSTYHVRPL ASDAQEKAPY
CGFYSAEHPM DFIRRLNCVR NLNLSELTNS VSQTECPKRC SFFHYESQLS AADWFPRLWQ
IHWMSDISSA LNALSERPVS RKAVEKLEQL LSFSQLELIA TAPQVTRLRR LEKRLSKKMA
LVTVSRFDYT TQVNRETLQI SLSALLSRLG GMGGLTLGVT VTTAFELLEL LYLSSKRLLQ
SCGFTAKQPA AAGAGATEEA DENFARALGS LPRSRQNGDF RTAANILKML KLNCLC
//
