ID A0A267DPI3_9PLAT Unreviewed; 775 AA.
AC A0A267DPI3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 13-SEP-2023, entry version 20.
DE RecName: Full=DIX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig004043g2 {ECO:0000313|EMBL:PAA51095.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA51095.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA51095.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA51095.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA51095.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA51095.1}.
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DR EMBL; NIVC01003505; PAA51095.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DPI3; -.
DR STRING; 282301.A0A267DPI3; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF2; AXIN; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 123..252
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 692..775
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 83763 MW; C082586A3477911C CRC64;
MTATELCCQQ QSPVSLTTTG DSTASPAIGQ QQQQQQQQQQ QLQDASQQQS LKSQQKHQQL
YMLAAAAAAA AAASTSDIPE EDDSASLTAT AAAATAGADE PDFASNIDGV SLAPVGVDVW
PEGLRNLLED AEAVLTFRNY LEEACDPAAA RAFDFYFAVK GLKSGQLQME QSTGDAGTSR
RCPKLIRLIA KRYILSEDSA VPVISSATRQ AVQSSLRSGS PADATIFDSA LAEAASYLAD
TAYPAFLRSD RWLGCADRLP TLHEDRELLL KAHGLLQQQQ QQQGGPVLVG LTRDNLLATR
HHRGRGGGSD RLMPAGPSCC TSMSQALPYY TSYAPGSRRD SELQSLQSSD ALTDVDNLSL
TDTASSLDAA SYRQHHHHHQ APGSRKGLRR AMRCAASANR DDLASNGGGS GASSSCRQQL
LLRHQLQQHA ASCQYDRDLP VTNPDKFARL LADRLQCHQR EQTLTSRPPS SLSCGSGAEL
LNSPWAQRIL RASMSSRDSN PEDILTDHLD HLDRGHSSHP QPLAPPPPQQ LPSSQPPPLQ
QQLHQKLEAS ELDQETHVHH YHYYHHFRAS GSGATNSLIC GGAGAASTAG DSGFGTISSS
SRYGGILRSS SATAAAASVA STSTGGSVHR QQLTQHVSNQ LAAAARCDQP RQPFMIDSNM
PVMDKPNPDT TIVEARRRLE EVSLQQQPPP QQQPLTIGYF LCGDSVPYRH AWPGQSITLG
QFKQLMAKKG SYRYFFKRRC DEFVVGGAVH EEVTDDSEVL PLWEGKVIGR VERVE
//
