ID   A0A267DSB4_9PLAT        Unreviewed;      1819 AA.
AC   A0A267DSB4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAA52173.1};
GN   ORFNames=BOX15_Mlig019232g3 {ECO:0000313|EMBL:PAA52173.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA52173.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA52173.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA52173.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA52173.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA52173.1}.
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DR   EMBL; NIVC01003288; PAA52173.1; -; Genomic_DNA.
DR   STRING; 282301.A0A267DSB4; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR   PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1352..1374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1410..1432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1534..1553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1559..1580
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1592..1611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1659..1687
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1027..1115
FT                   /note="RyR/IP3R Homology associated"
FT                   /evidence="ECO:0000259|Pfam:PF08454"
FT   DOMAIN          1562..1697
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          1458..1510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1485..1506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1819 AA;  210809 MW;  F8CE538AE63FC18B CRC64;
     MQTSKGGAAG GASGNEDKIL DLMDWAEKYL LESRHMVQDN FAENVFLKQV FELIAVLVKF
     GFYSEQVACA RLSDTILEVL DGRTDYPSLK LRDEHRAESE KALLRRFRET DRYRVKFENR
     FMLKAKVRGI DVLTLIMDQV KNQCLGEYIR LFIAAKHYRQ EEANLRICTF LSILDEDFNP
     DASDAKSQRQ VAKMKQQIIQ MYNSVQVINM QRFQSVMLDL ALYSTDDLVQ KATAAMCKYF
     FAKSGMYESA RRAYFCSTEE SRRLHLRLLN KMPKLRILIH SQWGKHNCRR MIRILRELTG
     YCRYQGQPHL INQMIILSHD AMDLVDGILS RPHHTLETED QHDELFQEMV NFIDVWCRGN
     DVISQQVFQR MPFILSLEHN YASTVPLFIG VFQQCAAFQE QMTERDFKQI IDIAIKCQRK
     LPEVFYLLIR STYSSSTADL NLRNISIIIK LVMENYSRMG GISGDWRAWK EALEDPESSD
     YYLAFLELLT CCCRTDRSFI ESMCMKMFRL EDVVKCTVNA DSFRMKAVLI RFFDEVFVSA
     ASDRLETRID ELQYNPELWQ LMLLCAEDID AIVRSLEELP QEEICMIMKA QEVKQPAGNF
     NVMSGMELKV NYIMDGLLPM TVSLLSRVFY PMALTDESAK ASFEQFLSSL NSFACLVSQY
     AMNQYQLCTL LGWFEKVEQM KAETLNRVSA WHSELVKMID AAKDACTVMG YFAEKHVIGE
     EERLALISHF AEELTTYDEF IKFNDRCRRV YEGRNTVEAQ VHGVDRNPAC YSEIGTVKEL
     PLGEEFQHFI DTFLDKNYSD LIPEHWRNRY RNLGVLVAQV HSAGLLSGLR GREKERQEEL
     NVRCLQVLRG AIHNQVVKLP DDWENRLREP KIIFQLRHIR AIQLAISQHN PNEAMSAHLI
     DPLSKSSKQI YAFLQMLLFN VSEVQQQDMI DFFVTTRVEH FFCALDSLLK DLGLQIKRRR
     DARRKREFTE QRGRFAFNEQ FELVRLASDS IRYTEANLKR KSDAQRYAMY TQLEEPQSSL
     QDGTGECTMK IMSQMCDGQF KPLQNYLRVQ EDNYTSFNVL NNLASVVHLI YANVDCENID
     LLVAMLDTLN EVAAGNHSNR IELVNNKVVD VLNVLLRTRE LPDCSPQQVL ALREMMANVL
     ITLVEENGPQ EASLAEEIKN TIDVAAMYKL MAQLAGMSKP AAEPDLQDLV RLPRKVRLPS
     TCIGRFGWRL RESRVAKFYR LRKLEDVKQD LVEVGFKYFI VLARFNDLDK ELYKRIDDPD
     REYLKAYKYM SKFGDSVEIV KDECLHRVHF RVQSRHVLRE EVKEDIKWKT NFWDPSEKQR
     DLLSWADSVI LDVTYTTRIL KNPIAMFLSR LWLVWNWLPV LISLAITILS MIAFKPKWAY
     RMALPPNTTV TPPAQVYDAV PDVKSDLRPA IFGLALVHSF VCAILFASFV LLNRPGWNNL
     AGLRKLFTCR GWTLSKLSKT TSSPSSGADA EEDDSVSDVD VGEADGGANR GKSEGMKGRG
     DGGQEEVGGD EIQDEYTEAK RINRLEVHFI GPETFYYGLL LVLSVLGTIF GYYDNWGYYL
     FAFHHINIFA GNVVLQNVVY TLKSASSTML SILVMAFLML YILSIFNFAF FRYNVFSDDN
     WYCETMFQCF VCFIRQGLIF DKWIDVFMPK NEPIKEFDFL LPSFFITMAT FVIIFVLLLN
     IIAGVILDKF SETRRETERK KADMVTGCLL CNRSSFEFET KASGFYHHVE NEHNLWAYFY
     YLIYLHQTKV NDLTALDLHV VKLWNEKSLE FLPMGRAMSL EDQKADQDQL KINAIDAMLQ
     WLKECKHEQV SYLGSSKDY
//