ID   A0A267DU86_9PLAT        Unreviewed;       831 AA.
AC   A0A267DU86;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=SH3 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BOX15_Mlig010956g1 {ECO:0000313|EMBL:PAA52805.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA52805.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA52805.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA52805.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA52805.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA52805.1}.
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DR   EMBL; NIVC01003180; PAA52805.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267DU86; -.
DR   STRING; 282301.A0A267DU86; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR   InterPro; IPR033635; ANKS1/Caskin.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR24174:SF16; CASKIN-1; 1.
DR   Pfam; PF00536; SAM_1; 2.
DR   SMART; SM00454; SAM; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          80..144
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          427..487
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          144..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          535..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..520
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..600
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   831 AA;  88800 MW;  B0B9E9C2044CD238 CRC64;
     MDHQLDLSSL PPPPPEFFLD NFDNDEEFIF SNSNCKDYNC TIKQGIDPGL TNAHGRTAKE
     VIARDTPFAR ELHQILYERI SAVAAVAIRD FCNLADPRSI AFRAGEHLTV LERTNGDTWK
     GYVTREGLSR AGYFPCSAVR LLEQPQQQQQ QQQHQQRQDP PTCLSSSLMH QSQPHQMPPV
     SQSTPASNAA VSPTSGSNNR NSAASLDSGR SSSHTATSSD TRSAVAVTAS GPSGPAGANS
     STGSAAAAAA ASAGTMCSRV LNSATNTPRS AAAPAAANGS VDSGLGPHRQ SMVSTCSSGS
     LGSLPDDNSS AASVSSGELQ YQQQQQHGWL REDWRSLTSS QQLHRFLDWC QLACYHRSIE
     EAGYDLATLV RCTPEDLNAA GVTNPRHRKR LRSDLARLGQ AMQAGQAPGG LPDPIEDAVC
     LTADAALTEL CCRLGLPDTA SACLRRAGFQ LVRDLGQMAW EDLEEIGISR LGHQKKLMLV
     IDRLRRPRHG PESDQHQPDQ QQGTLRRQSA KSTVSCGTCT SSDSIAVQPD PFLAAESQQQ
     PPQSPPQPSC HSRSFSGSGA AQQSVKLLGR PIPVAVPEVP PQQPPPTPQR GAPPPPPKRV
     TSVRRCSGDA GSVTPCASPS TTPRHQAARP PAYENAAALA DSPALARLGA AASAMPFANE
     DCGTIRHKPA SASIAAAVAS PQFGRAALFQ QHRQHQHQLH HQLQHLPASP AFARRVPASA
     AAAAAAAPPT PSRWVLQPPP PREDPARTWT TSAACCPSCS ATLTASCRSS ARGRAELQMS
     STLLISQCTC CVMLVFYYRN SPFYLFISNL TTPPPLSSYR FLCHFFISFV H
//