ID A0A267DVI5_9PLAT Unreviewed; 464 AA.
AC A0A267DVI5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN ORFNames=BOX15_Mlig033049g2 {ECO:0000313|EMBL:PAA52674.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA52674.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA52674.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA52674.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA52674.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA52674.1}.
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DR EMBL; NIVC01003201; PAA52674.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267DVI5; -.
DR STRING; 282301.A0A267DVI5; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd22401; KH-I_IGF2BP_rpt2; 1.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF337; IGF-II MRNA-BINDING PROTEIN, ISOFORM L; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 72..145
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..453
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 49385 MW; 57BE3ADFC71F2D19 CRC64;
MSSEQEIAPA GNAAADGQHQ PVAEDAQTIV EPANSVNNNS DASVGDADTS ATIAAPAKLN
GLATSGGIKK SQRVRVMGAS GKHNDKDLAE MFGKYGDVAK IEPHNYQEGV LVVSMDCVDS
ANRAVAELNN VEFQGQKLIL NNDSANQRRL NQQRRSAPPA TSLPLRENYP LRILINSDLV
GAIIGKGGET IKEITNKTKA RVDVKREVVQ KNAQPKKSSP RSPEKGDATE ATALSERLQI
VFVYGSPESC SDACREIMSI CIGEAKEKGK EEPDLGILAE DRFCGRIIGK DGKNLNTIRE
KSKTSIQLSN SPTITTYDSS SPTFSLDRII TVKGSLEGMC QAEKFLSEKL RQCHTIDMQQ
YSYAPSVSQG YPAPYQPAEF GYPAPVPGML PAPGAPLPGY SAPGFRLGMP ANPTAATFAP
LPSPSAAAAA QYGAAAMQAP TQPPPPPPQP LPAHHHQQHI TEAI
//
