ID   A0A267DWM8_9PLAT        Unreviewed;       911 AA.
AC   A0A267DWM8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=BOX15_Mlig017287g1 {ECO:0000313|EMBL:PAA53596.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA53596.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA53596.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA53596.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA53596.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA53596.1}.
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DR   EMBL; NIVC01003057; PAA53596.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267DWM8; -.
DR   STRING; 282301.A0A267DWM8; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR   InterPro; IPR032353; AZUL.
DR   InterPro; IPR042556; AZUL_sf.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF16558; AZUL; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          583..911
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          75..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        879
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   911 AA;  102129 MW;  6D1A0FA21DE0851D CRC64;
     MAASSSRERI AISIKDHFQR LTVGCGDASC LSPHCASSQQ FRHSQLGGNK NSLALLAVEL
     AKSDTEVCGN ASLVRQTSSN SGKRSVSPPI VLESSGGGSG GGGESRSSVG SVSEGAAMAM
     MDINDSEVGA AAAVAFAPTP NREVLGMQTV ESHNSSAMNE NQSESVRLNQ PQQPLPSPPP
     IDEVFNEATL RRMSGQPDKQ PLIRLLSSVF TSPERTVEAF RPSHGVDDDG VHEKHESELS
     EKNAADALAR IDVHCVHTLT RLIPYEKSVM DPLCGSVNFL CRQVRLELSD HPRPLHLCVA
     AVLFEFSVLF DPNNMETVVP SICMLAGRLP TEHQAALIHF WCRHKTVEDL RMLLLVLMQL
     LTLRCLLMEN EAGEESERSL NEDAVICDVC RVIKLVYYAS GLLGDVDSRQ ALAREREKTE
     TFLASLNALY DRTNLPDRRR QGHQLWKPDP LAEQLCFRRP ADCIRPAIPD EEFINDTLNE
     LMSVDRDYNF FLESDRSPTL ANRQRDEMPP FSFLNHPFLL TTFTKSVALY LDSRIRMFRE
     RRGALLQSLM LHSDHNMYLR INVRRANIVQ DALLTLEMVG LESPGDLKKQ LVIEFEGEQG
     IDEGGLSKEF FQLIIEQIFN PDYGMFSLNQ RTQSFWFYPG SEDCEREFVL VGMLLGLAIY
     NNIILDVRFP TVLYKKLTGK LGAFHDLKGS HPELAQGMQQ LLEYDGDSFE DIFGCFSISF
     QDAFGSTLNH ELKPDGANIP VTKENRQEFV DLYSDFLLNG MIEKQFNAFC KGFHLVIDNS
     LLLQLFAPTE IELLVCGSKT YNFHELQKYT QYDGGYTENS PIIAHFWKLV HTMSDVDKRL
     LLEFVTGSDR VPLGGMKKMK FIIARQGPDT DRLPTAHTCF NVLLLPEYSS YDKLQDRLLK
     AIANSKGFGM L
//