ID A0A267E1J4_9PLAT Unreviewed; 564 AA.
AC A0A267E1J4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=E2F/DP family winged-helix DNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOX15_Mlig014863g2 {ECO:0000313|EMBL:PAA55425.1},
GN BOX15_Mlig014863g3 {ECO:0000313|EMBL:PAA77552.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA55425.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA55425.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA55425.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA55425.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA55425.1}.
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DR EMBL; NIVC01002755; PAA55425.1; -; Genomic_DNA.
DR EMBL; NIVC01000735; PAA77552.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267E1J4; -.
DR STRING; 282301.A0A267E1J4; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR015648; Transcrpt_fac_DP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR PANTHER; PTHR12548:SF9; TRANSCRIPTION FACTOR DP; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transcription {ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 263..345
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 352..490
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 32..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 60762 MW; 782BDDE012C15095 CRC64;
MDVDVESLDF MESDVAEEVV VGNAAESSAF ASAQLRESSG GQLKREPTTT RVEESPGGEA
RQPTVIQVHP SAAASQPRVI RIQTTAGSAG HSVAMAAPTV SSAGAGGVGD GSGKPVRVIR
LPVQKLAAGS QQSGTGSIKI ITLPPRSQQQ QQQQIVRQVG PGGMQQQGGQ TLRVITAAGA
QRIIQVRSLP MQQQQQQQRK LGSGAVQARG FLPDPKLKAV TPTSVRGGAG FGLGFAPRAR
GSAGPAGAED WMDDDDYAGS GARGGSGLRK YAGAVVEKLQ NKTITSYYEV ADELVHEFAA
EHPLMPQDQL IYHQKNIRRR AYDTLNVLLA MGVIRRDNKE ITWVGMPLNA IVQCRKLQEE
REERLKRIRE KANEISEKVC QLIAFKQLVK RNRENEQMYG QAPKASLLHL PFLVISCPPN
TVTDCNITKD KLEYLFTFDH TFEISDDTAV LRSLGYQLAT NNEPVDDIIE SVPPSLRFFV
NALYERREAV VPDFESVHAQ RKLEAAAAGA AAAAGAGMPQ IIQAIPSAVV GGIGHHHPHS
QMVPLSDSEI EEEEGSDIEV EVGA
//
