ID A0A267E3D7_9PLAT Unreviewed; 398 AA.
AC A0A267E3D7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Guanine nucleotide-binding protein G(O) subunit alpha {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=BOX15_Mlig013143g2 {ECO:0000313|EMBL:PAA55349.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA55349.1, ECO:0000313|Proteomes:UP000215902};
RN [1] {ECO:0000313|EMBL:PAA55349.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA55349.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA55349.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The
CC alpha chain contains the guanine nucleotide binding site.
CC {ECO:0000256|ARBA:ARBA00011356}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAA55349.1}.
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DR EMBL; NIVC01002767; PAA55349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A267E3D7; -.
DR STRING; 282301.A0A267E3D7; -.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF355; GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PAA55349.1"
SQ SEQUENCE 398 AA; 45315 MW; 4CB6086AB54BF5EC CRC64;
KHHLQTNLSS SISINSFPRC WLSSSLNTYF NFLSHRSSHP SAAVMGCTLS AEERQAQEQS
KTIDRLLKED GVQAAKDIKL LLLGAGESGK STIVKQMKII HEGGFTQEDN KQYKPVVYSN
TIQSLVAILR AMTTLGISYG DSERQADSRL VFDVIGRMED TEPFSDELLA AMKRLWADSG
VQQCFGRSNE YQLNDSAKYF LDDLDRLGAK AYMPTEQDIL RTRVKTTGIV EVHFVFKNLN
FKLFDVGGQR SERKKWIHCF EDVTAIIFCV AMSEYDQVLH EDETTNRMQE SLKLFDSICN
NKWFTETSII LFLNKKDLFE EKIKRSPLTT CFPEYCGKQT YEEAAAYIQA QFEAKNKSPN
KEIYCHQTCA TDTNNIQFVF DAVTDVIIAN NLRGCGLY
//
