ID   A0A267E508_9PLAT        Unreviewed;       846 AA.
AC   A0A267E508;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=TTF-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BOX15_Mlig007787g1 {ECO:0000313|EMBL:PAA56516.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|EMBL:PAA56516.1, ECO:0000313|Proteomes:UP000215902};
RN   [1] {ECO:0000313|EMBL:PAA56516.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA56516.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA56516.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAA56516.1}.
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DR   EMBL; NIVC01002611; PAA56516.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A267E508; -.
DR   STRING; 282301.A0A267E508; -.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR025398; DUF4371.
DR   InterPro; IPR008906; HATC_C_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   PANTHER; PTHR46289; 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR46289:SF14; DIMER_TNP_HAT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR   Pfam; PF14291; DUF4371; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215902}.
FT   DOMAIN          221..440
FT                   /note="DUF4371"
FT                   /evidence="ECO:0000259|Pfam:PF14291"
FT   DOMAIN          766..825
FT                   /note="HAT C-terminal dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF05699"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  94394 MW;  EC1F40AA4EBF16EE CRC64;
     MSKRKSHGHD IRSLFENLKR SRPNPDPALL STPSSSTTQP DSSIVSCDTA TGSLPDLATP
     NSVPTAPEQQ LQATITSSSQ FDESDLQHQA DEAAAETEIN VNDIGYAVEL RRDGKLDTAT
     RLRFLKDCWV PPQGYSFPFT LKSDKGNVHK RYLSHQHLTG HNACFAYSAK LGGVFCKYCV
     LFLPTNFAIH GQTVDAFVGT PCTKFDVITT KLKKHLQCDY HRSDSVIKAD ALLSGTNVGH
     MLDVSRAKLV KENRERLKHV IEPIEFLARC GLAFRGHRDF GPIKVHPDGT IDYDKGNFVA
     LLQLLAKHDP ILREHICTGP SNAKYTSSES QNEIIQALSD VITQDLVKKI NKAGYFALLA
     DETTDSSHKE QMSICVRYLD ISDGSVAIHE EFICFVHVED LTGIGLATKL LETLDSLHIT
     AQLVAQGYDG ASAMSGKFNG VQAVIREQLG KKLAIYVHCA AHNLNLSLQD ACKLDSVRAA
     ITAVNTVTVF IRSSPQRTAL LEKKIKELVP ESSVHQLLQH CKTRWVEKQE AFIRFNLLFP
     AIIETLEEIS TWGGEAGSNA RNNLKLLLDS EYVIAGHIID AVLTITKPLS EKLQCVDLDL
     VDCVNEIKAV IDVLRDLRSD DGHVRYNKIF DSAEKALGEP LQKPRTSARC RQKHRANPDV
     STARDYFRIA MYNPFLDGII ATLEERFSSH AQLAFQMARL LPQSVVDESF DSVKKSIEIY
     IGQLRGLSFV DDIEAEFLLW KKRWQNVDQK DRPRSVLETL ANSAVSLQSF PNIRLLLQVL
     ATIPVTTATA ERSFSQLRPL KSYLRSTMGQ ERLTGLAQLL IHKDMKLDID KVIDQFVQNG
     SRRIDL
//